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Molecular and neural basis for ultrasonic vocalizations as the emotional expression in male mice

Research Project

Project/Area Number 18K13371
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionKagoshima University

Principal Investigator

Kanno Kouta  鹿児島大学, 法文教育学域法文学系, 准教授 (80722470)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords音声コミュニケーション / 超音波発声 / マウス / 情動表出 / ドーパミン / 求愛 / マウス超音波発声 / 個体差 / USVs
Outline of Final Research Achievements

Vocal communication in mice has attracted numerous research interests in recent years, as it has been analyzed in genetically modified mouse models of disease. Nevertheless, the neural mechanisms are still unclear, and the "meaning" (biological significance) of each vocalization remains unclear. In this study, we showed that ultrasonic courtship vocalizations in male mice occur as a strong emotional expression. In addition, we showed that ultrasonic vocalizations vary depending on social contexts and are not simply expressed as interest in or attention to novel environments or individuals. Besides, we developed a program to analyze ultrasonic vocalizations with high accuracy and established an experimental system to analyze neural activities in real-time during vocalization, thus establishing experimental and analytical techniques for rodent ultrasonic vocalizations.

Academic Significance and Societal Importance of the Research Achievements

マウス超音波発声の発声内容に含まれる「意味」が不明瞭なまま研究に用いられてきたことは、上述の通りである。本研究、もしくは申請者は、これまでに一貫して発声とその内容が示す生物学的意義を研究してきた。このことにより、各病態モデルマウスにおいて、齧歯類超音波発声がどのようなモデルとして有用であるか、議論が可能になっていくと期待している。さらに、高精度な実験・解析手法が蓄積されたことにより、動物実験心理学や神経科学分野の研究者に広く技術を提供することにもつながる。また、本研究は、感情表現にも繋がる情動の表出とそのメカニズムを探るもので、そのような基礎研究の進展に貢献する意義を持つ。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Remarks (2 results)

  • [Journal Article] Sexual excitation induces courtship ultrasonic vocalizations and cataplexy-like behavior in orexin neuron-ablated male mice2021

    • Author(s)
      Kuwaki Tomoyuki、Kanno Kouta
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1

    • DOI

      10.1038/s42003-021-01696-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AUTS2 regulation of synapses for proper synaptic inputs and social communication.2020

    • Author(s)
      Hori Kei、Yamashiro Kunihiko、Nagai Taku、... Yamada Mitsuhiko、Yamada Kiyofumi、Hoshino Mikio
    • Journal Title

      iScience

      Volume: ー Issue: 6 Pages: 101183-101183

    • DOI

      10.1016/j.isci.2020.101183

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex differences in vocalizations to familiar or unfamiliar females in mice2020

    • Author(s)
      Sasaki Eri、Tomita Yuiri、Kanno Kouta
    • Journal Title

      Royal Society Open Science

      Volume: 7 Issue: 12 Pages: 201529-201529

    • DOI

      10.1098/rsos.201529

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] USVSEG: A robust method for segmentation of ultrasonic vocalizations in rodents2020

    • Author(s)
      Tachibana Ryosuke O.、Kanno Kouta、Okabe Shota、Kobayasi Kohta I.、Okanoya Kazuo
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 2 Pages: 1-16

    • DOI

      10.1371/journal.pone.0228907

    • URL

      https://pure.teikyo.jp/en/publications/0fe7a9d6-d311-46af-aac5-253918586d81

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] USVSEG: A robust segmentation of rodents’ ultrasonic vocalization2019

    • Author(s)
      Tachibana Ryosuke O.、Kanno Kouta、Okabe Shota、Kobayasi Kohta I.、Okanoya Kazuo
    • Journal Title

      BioRxiv(プレプリント)

      Volume: -

    • DOI

      10.1101/572743

    • Related Report
      2018 Research-status Report
    • Open Access
  • [Journal Article] Effect of Sociosexual Experience and Aging on Number of Courtship Ultrasonic Vocalizations in Male Mice2018

    • Author(s)
      Kanno Kouta、Kikusui Takefumi
    • Journal Title

      Zoological Science

      Volume: 35 Issue: 3 Pages: 208-214

    • DOI

      10.2108/zs170175

    • NAID

      40021616693

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生物学的視点から見る絆形成の行動科学・心理学 : 動物,ロボット,想像上の他者2018

    • Author(s)
      菅野康太
    • Journal Title

      行動科学

      Volume: 57 Pages: 41-45

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of prenatal and/or postnatal SSRI exposure on vocal behavior in mice2020

    • Author(s)
      Ziguo Lan, Kouta Kanno
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マウスの音声コミュニケーション2019

    • Author(s)
      菅野康太
    • Organizer
      第72回 日本自律神経学会総会 シンポジウム6「自律神経研究へアプローチする新しい方法論」(招待講演)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 動物心理学におけるマウス超音波発声の今後の可能性2019

    • Author(s)
      菅野康太
    • Organizer
      日本動物心理学会第79回大会 自由集会「動物行動実験・解析手法の展開」
    • Related Report
      2019 Research-status Report
  • [Presentation] Individual differences of courtship ultrasonic vocalizations in male mice2018

    • Author(s)
      Kouta Kanno
    • Organizer
      生物音響学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 指定討論2018

    • Author(s)
      菅野康太
    • Organizer
      日本心理学会第82回大会シンポジウム「動物を人の心のモデルとすることの意義」
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 個性を生物学で記述したいけどできるだろうか2018

    • Author(s)
      菅野康太
    • Organizer
      日仏哲学会プレイヴェント企画「見果てぬ哲学」 第二部「来るべき哲学:提言と討論」
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 情動表出としてのマウス超音波発声およびその個体差2018

    • Author(s)
      菅野康太
    • Organizer
      日本神経科学大会第41回大会シンポジウム「個性と身体表現の創発に関わる神経機構」
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 菅野康太2018

    • Author(s)
      マウス音声コミュニケーションの個体差に表現される生物学的意義
    • Organizer
      日本赤ちゃん学会2018 第18回学術集会 自主企画ラウンドテーブル 「コミュニケーション発達における多様性と共通性 発達期における情報授受成立の兆し」
    • Related Report
      2018 Research-status Report
  • [Remarks] 菅野研究室website

    • URL

      https://cannonolab.com

    • Related Report
      2020 Annual Research Report
  • [Remarks] 菅野研究室HP

    • URL

      https://cannonolab.com

    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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