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Continuum theory of growing cellular tissues and its application to organ formation

Research Project

Project/Area Number 18K13516
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
Research InstitutionJapan Atomic Energy Agency (2021-2023)
Kyushu University (2018-2020)

Principal Investigator

Yabunaka Shunsuke  国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 原子力科学研究所 先端基礎研究センター, 任期付研究員 (60749852)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細胞競合 / 細胞選別 / 細胞組織 / 温度勾配 / 臨界現象 / 繰り込み群 / 2成分流体 / 二成分流体 / 極性 / 相分離 / 2成分流体 / 非平衡クロス効果 / 連続体理論 / 極性の記憶効果 / 界面の安定性 / 数理モデル / アクティブマター / 増殖 / ソフトマター
Outline of Final Research Achievements

We developed a continuum theory that incorporates the effects of cell proliferation and a numerical scheme for its numerical analysis. We further extended the theory to the case of a two-cell system and constructed a continuum theory describing the effects of cell sorting and cell competition. Numerical analysis of the cell sorting situation revealed that, depending on the asymmetry in the dynamic properties of the two types of cells (difference in their motility), nonequilibrium phase separation phenomena arise, which do not occur in equilibrium systems. We also conducted basic research on the theory of phase transition near equilibrium, which is the mother of such a theory, and clarified the structure of the fixed point of the renormalization group of the O(N) model, which was previously unknown, and the transport properties under a temperature gradient of a binary mixture near the critical point.

Academic Significance and Societal Importance of the Research Achievements

細胞組織のダイナミクスの理論的な理解は、生体組織の形成を理解する上で重要であり、長期的な視野においては医療への応用が見込まれると考えられる。また細管中の二成分混合系における輸送特性の理解は、非平衡環境下での物質輸送特に、浄化、あるいは、濃縮などの技術への応用につながると考えられる。さらに繰り込み群による相転移現象の基礎付けは、物性物理の幅広い分野に加え、原子核、素粒子を記述するモデルである場の理論を深く理解する上で重要である。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] パリ大学(フランス)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] キュリー研究所(フランス)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] キュリー研究所/パリ第6大学(フランス)

    • Related Report
      2018 Research-status Report
  • [Journal Article] One Fixed Point Can Hide Another One: Nonperturbative Behavior of the Tetracritical Fixed Point of O(N) Models2023

    • Author(s)
      Yabunaka Shunsuke、Delamotte Bertrand
    • Journal Title

      Physical Review Letters

      Volume: 130 Issue: 26

    • DOI

      10.1103/physrevlett.130.261602

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Isothermal transport of a near-critical binary fluid mixture through a capillary tube with the preferential adsorption2022

    • Author(s)
      Shunsuke Yabunaka and Youhei Fujitani
    • Journal Title

      Physics of Flluids

      Volume: - Issue: 5

    • DOI

      10.1063/5.0090218

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polarity Fluctuation Inhibition by Memory in Collective Cell Motion2021

    • Author(s)
      Katsuyoshi Matsushita, Shunsuke Yabunaka and Koichi Fujimoto
    • Journal Title

      Journal of the Physical Society of Japan

      Volume: 90 Issue: 5 Pages: 054801-054801

    • DOI

      10.7566/jpsj.90.054801

    • NAID

      40022563209

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Drag coefficient of a rigid spherical particle in a near-critical binary fluid mixture, beyond the regime of the Gaussian model2020

    • Author(s)
      Yabunaka Shunsuke、Fujitani Youhei
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 886 Pages: 1-23

    • DOI

      10.1017/jfm.2019.1020

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crowding-Boosting Polarity and Motion Order of Cells2019

    • Author(s)
      Katsuyoshi Matsushita, Kazuya Horibe, Naoya Kamamoto, Shunsuke Yabunaka, Koichi Fujimoto
    • Journal Title

      Proceedings of the Symposium on Simulation of Traffic Flow

      Volume: 25 Pages: 21-24

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Why Might the Standard Large N Analysis Fail in the O(N) Model: The Role of Cusps in Fixed Point Potentials2018

    • Author(s)
      Yabunaka Shunsuke、Delamotte Bertrand
    • Journal Title

      Physical Review Letters

      Volume: 121 Issue: 23

    • DOI

      10.1103/physrevlett.121.231601

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chapter 14. Theory of Active Particles and Drops Driven by Chemical Reactions: The Role of Hydrodynamics on Self-propulsion and Collective Behaviours2018

    • Author(s)
      Yoshinaga N.、Yabunaka S.
    • Journal Title

      Self-organized Motion: Physicochemical Design based on Nonlinear Dynamics

      Volume: 1 Pages: 339-365

    • DOI

      10.1039/9781788013499-00339

    • ISBN
      9781788011662
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] A Fixed point can hide another one; The Nonperturbative behavior of the tetracritical fixed point of the O(N) models at large N2023

    • Author(s)
      S. Yabunaka, B. Delamotte
    • Organizer
      Exploring New Topics with Functional Renormalisation, Bad Honnef, Germany
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thermoosmosis of a near-critical binary fluid mixture under preferential adsorption: universal flow properties2023

    • Author(s)
      S. Yabunaka and Y. Fujitani
    • Organizer
      ISMC 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 選択的吸着効果の下での2元混合系の毛管中質量流の臨界点近くのスケーリング則2022

    • Author(s)
      藪中俊介
    • Organizer
      日本物理学会 2022年秋季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 温度勾配下での相分離系の液滴のダイナミクス2021

    • Author(s)
      木下智貴, 藪中俊介
    • Organizer
      物理学会2021年秋季大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 選択的吸着効果のもとでの毛細管中の臨界点近くの二元混合系の浸透現象2020

    • Author(s)
      藪中俊介
    • Organizer
      日本物理学会2020年秋季大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 臨界点近くの2成分混合系中のコロイドの抵抗係数2019

    • Author(s)
      藪中俊介
    • Organizer
      ソフトマター研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 球および円柱の周りの臨界吸着プロファイルのLocal renormalized functional theoryによる解析2018

    • Author(s)
      藪中俊介
    • Organizer
      日本物理学会秋季学会
    • Related Report
      2018 Research-status Report
  • [Presentation] O(N)模型、O(N)*O(2)模型の新しいLarge-N極限:非摂動的固定点の役割2018

    • Author(s)
      藪中俊介
    • Organizer
      日本物理学会秋季学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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