| Project/Area Number |
18K14252
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | Kobe University |
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Principal Investigator |
TAKANO eri 神戸大学, 工学研究科, 学術研究員 (20634645)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子認識 / バイオマーカー / 表面プラズモン励起増強蛍光 / 分子インプリンティング / 全自動分析装置 |
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| Outline of Final Research Achievements |
In this study, prostate-specific antigen (PSA), which is a biomarker glycoprotein for prostate cancer, was used as a model. We tried to recognize sugar chains of PSA to detect the cancer-related PSA by fluorescent molecularly imprinted polymers bearing fluorescent signaling sites (F-MIPs). Antibodies for glycan are difficult to prepare, therefore, F-MIPs could be useful for the substitution of antibodies for glycoproteins.
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| Academic Significance and Societal Importance of the Research Achievements |
SPFセンシングは、従来の蛍光に比べて数十倍から数百倍の高感度で検出できるので、このセンシングが実現できれば、これまで見過ごされてきた擢患初期の情報を得ることがき、学術的に意義がある。また、進行した癌の動態の把握のみならず、早期診断あるいは予後診断のためにも有効で、社会的にも波及効果がある。
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