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Microspectroscopic molecular detection based on liquid-liquid interface-assisted optical tweezers

Research Project

Project/Area Number 18K14254
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 34020:Analytical chemistry-related
Research InstitutionOsaka City University

Principal Investigator

Shoji Tatsuya  大阪市立大学, 大学院理学研究科, 講師 (90701699)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords光ピンセット / 液液界面 / 顕微蛍光分光法 / 分子濃縮 / 金ナノ粒子 / 量子ドット / 顕微分光 / 油水界面 / 温度応答性高分子 / 顕微分光分析 / 抽出・濃縮法
Outline of Final Research Achievements

Optical trapping (OT) at a liquid/liquid (L/L) interface involves a wealth of chemical interest. However, it has been limited so far. We demonstrated optical trapping and micro-assembly formation of polystyrene beads at a L/L interface. We found that polystyrene microspheres were efficiently trapped at a water/hexane interface. During near-infrared laser irradiation, numerous particles were trapped even at the outside of the irradiation area. These unique trapping behaviors indicated that a L/L interface has some assisted effects in OT. The effect would be caused by a light propagation among the trapped polystyrene beads and by suppresses the diffusive motion of the beads at the interface by the surface tension forces.
We named this novel OT at L/L interface “LiLiI-OT (Liquid/Liquid Interface-assisted OT)” We believe that LiLiI-OT will become a powerful manipulation technique toward analytical chemistry.

Academic Significance and Societal Importance of the Research Achievements

金や銀などの貴金属ナノ粒子に共鳴光を照射すると、単分子レベルの高感度分子検出が可能である。しかしながら、検出できる分子に成約がある。そこで水と油のような二つの液体から成る界面で貴金属ナノ粒子と高分子を光の力により捕まえ、水層と油層中に微量に溶解した有機分子を高感度に検出する新たな分析手法の開発を目指し研究を進めた。その結果、このような液液界面を利用すると貴金属ナノ粒子を効率よく捕捉することに成功した。今後、この手法を発展することで単分子レベルの高感度化を目指す。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (35 results)

All 2020 2019 2018 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (29 results) (of which Int'l Joint Research: 13 results,  Invited: 6 results) Remarks (2 results)

  • [Journal Article] Plasmonic Manipulation of DNA using a Combination of Optical and Thermophoretic Forces: Separation of Different-Sized DNA from Mixture Solution2020

    • Author(s)
      Shoji Tatsuya、Itoh Kenta、Saitoh Junki、Kitamura Noboru、Yoshii Takahiro、Murakoshi Kei、Yamada Yuto、Yokoyama Tomohiro、Ishihara Hajime、Tsuboi Yasuyuki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3349-3349

    • DOI

      10.1038/s41598-020-60165-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regular Assembly of Polymer Nanoparticles by Optical Trapping Enhanced with a Random Array of Si Needles for Reconfigurable Photonic Crystals in Liquid2019

    • Author(s)
      Hanasaki Itsuo、Shoji Tatsuya、Tsuboi Yasuyuki
    • Journal Title

      ACS Applied Nano Materials

      Volume: 2 Issue: 12 Pages: 7637-7643

    • DOI

      10.1021/acsanm.9b01707

    • NAID

      120006953138

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019586

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 分子操作を目指したナノ構造を用いた新奇光ピンセットの開発2019

    • Author(s)
      東海林 竜也
    • Journal Title

      光化学

      Volume: 1

    • NAID

      40021890105

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] ナノ構造体を用いる光ピンセットの開発2019

    • Author(s)
      東海林 竜也
    • Journal Title

      分析化学

      Volume: 5

    • NAID

      130007662341

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] ナノ構造を用いた光ピンセットの分析化学への展開2020

    • Author(s)
      東海林 竜也
    • Organizer
      電子情報技術部会 マイクロナノシステムと材料・加工分科会 講演会 「高感度分析を可能にするプラズモンナノ材料最前線」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Micro-assembly formation of soft nanomatters based on nanostructure-assisted optical tweezers2019

    • Author(s)
      Tatsuya Shoji
    • Organizer
      Fifteenth International Workshop on Supramolecular Nanoscience of Chemically Programmed Pigments (SNCPP19)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Plasmonic optical trapping of soft nanomaterials for analytical chemistry2019

    • Author(s)
      Tatsuya Shoji
    • Organizer
      The 3rd International Workshop on Optofluidics and Electrokinetics in Micro and Nanoscale Devices (OEMN2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fluorescence microspectroscopic study on a reagent release from an optically trapped single microcapsule for drug delivery2019

    • Author(s)
      Miyako Iida, Tatsuya Shoji, Yasuyuki Tsuboi
    • Organizer
      The 3rd International Workshop on Optofluidics and Electrokinetics in Micro and Nanoscale Devices (OEMN2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spectroscopic analysis of a single thermos-responsive polymer microdroplet formed by optical tweezers2019

    • Author(s)
      Jie Lu, Kayo Fujiwara, Tatsuya Shoji, Yasuyuki Tsuboi
    • Organizer
      The 3rd International Workshop on Optofluidics and Electrokinetics in Micro and Nanoscale Devices (OEMN2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Liquid/liquid interface-assisted (LiLiI) optical tweezers for micro-assembly formation of polystyrene nanospheres2019

    • Author(s)
      Tatsuya Shoji, Daiki Yamanishi, Yasuyuki Tsuboi
    • Organizer
      The International Symposium on Plasmonics and Nano-photonics (iSPN2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Size Selective Optical Trapping of Polystyrene Nanoparticles using Plasmonic and Non-plasmonic nanostructures2019

    • Author(s)
      Sayaka Hashimoto, Tatsuya Shoji, Saulius Juodkazis, Yasuyuki Tsuboi
    • Organizer
      Materials Research Meeting 2019 (MRM2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 光ピンセットを駆使した機能性ナノ材料の顕微分光分析法の開発2019

    • Author(s)
      東海林 竜也
    • Organizer
      超スマート社会の構築に繋がる革新的材料創出に向けた光・量子ビーム応用技術調査専門委員会 第2回委員会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 液/液界面を利用したポリスチレン微粒子の光捕捉2019

    • Author(s)
      山西 大樹, 東海林 竜也, 坪井 泰之
    • Organizer
      2019年光化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 液/液界面光ピンセットによるポリマービーズの高効率光捕捉2019

    • Author(s)
      山西 大樹, 仲 翔太, 東海林 竜也, 坪井 泰之
    • Organizer
      日本化学会 第99春季年会(2019)
    • Related Report
      2018 Research-status Report
  • [Presentation] Molecular condensation and spectroscopic detection based on plasmonic optical trapping of thermoresponsive polymer2018

    • Author(s)
      Tatsuya Shoji
    • Organizer
      Asian Pacific Society for Materials Research(APSMR)2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Optical Tweezers Combined with Raman Microspectroscopy for Micro-Analysis of a Single Micro-Droplet of Polyacrylamides2018

    • Author(s)
      Tatsuya Shoji, Mitsuhiro Matsumoto, Kayo Fujiwara, Yuta Koda, Hideo Horibe, Yasuyuki Tsuboi
    • Organizer
      The 10th Asian Photochemistry Conference (APC2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Liquid/liquid Interface-assisted Optical Trapping OF Semiconductor and Noble Metallic Nanocrystals2018

    • Author(s)
      Daiki Yamanishi, Shota Naka, Tatsuya Shoji, Seiya Koyama, Tatsuya Kameyama, Tsukasa Torimoto, Yasuyuki Tsuboi
    • Organizer
      The 10th Asian Photochemistry Conference (APC2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Trapping and micro-patterning of thermoresponsive polymer microgels by using plasmonic optical tweezers2018

    • Author(s)
      Tatsuya Shoji, Mitsuhiro Deguchi, Taka-aki Asoh, Yuriko Matsumura, Fumiya Katoh, Kei Murakoshi, Yasuyuki Tsuboi
    • Organizer
      The 12th International Conference on Excitonic and Photonic Processes in Condensed Matter and Nano Materials (EXCON2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient Optical Trapping of Noble Metallic and Semiconductor Nanoparticles at a Hexane-Water Interface2018

    • Author(s)
      Daiki Yamanishi, Shota Naka, Tatsuya Shoji, Seiya Koyama, Tatsuya Kameyama, Tsukasa Torimoto, Yasuyuki Tsuboi
    • Organizer
      The 12th International Conference on Excitonic and Photonic Processes in Condensed Matter and Nano Materials (EXCON2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient Optical Trapping of Noble Metallic and Semiconductor Nanocrystals at an Oil/Water interface2018

    • Author(s)
      Daiki Yamanishi, Shota Naka, Tatsuya Shoji, Seiya Koyama, Tatsuya Kameyama, Tsukasa Torimoto, Yasuyuki Tsuboi
    • Organizer
      2018 Hsinchu Summer Course and Workshop
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optical trapping of gold and semiconductor nanoparticles at oil-water interfaces with a focused near-infrared laser beam2018

    • Author(s)
      Tatsuya Shoji, Shota Naka, Tsukasa Torimoto, Yasuyuki Tsuboi
    • Organizer
      The 5th Optical Manipulation and Structured Materials Conference (OMC2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナノ構造体を用いた新奇光捕捉法の開発と展開2018

    • Author(s)
      東海林 竜也
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 液/液界面光ピンセットを用いた半導体・金属ナノ粒子の高効率光捕捉2018

    • Author(s)
      山西 大樹, 仲 翔太, 東海林 竜也, 小山 晟矢, 亀山 達矢, 鳥本 司, 坪井 泰之
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 温度応答性高分子水溶液の相分離速度の計測:親水性官能基の導入による相分離の加速2018

    • Author(s)
      北場 萌, 東海林 竜也, 藤原 華代, 松本 充央, 麻生 隆彬, 西山 聖, 堀邊 英夫, 坪井 泰之
    • Organizer
      第69回コロイドおよび界面化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 半導体ナノ構造表面上で捕捉したポリマー微粒子に作用する増強光圧の定量的評価2018

    • Author(s)
      荻田 修平, 東海林 竜也, Denver Linklater, Saulius Juodkazis, 加藤 郁也, 村越 敬, 坪井 泰之
    • Organizer
      第69回コロイドおよび界面化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 光捕捉-顕微ラマン分光法による相分離した種々の温度応答性高分子液滴中の高分子濃度解析2018

    • Author(s)
      藤原 華代, 東海林 竜也, 松本 充央, 麻生 隆彬, 堀邊 英夫, 西山 聖, 坪井 泰之
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 油水界面における金属・半導体ナノ結晶の高効率光捕捉2018

    • Author(s)
      山西 大樹, 仲 翔太, 東海林 竜也, 小山 晟矢, 亀山 達矢, 鳥本 司, 坪井 泰之
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Research-status Report
  • [Presentation] プラズモン増強光圧と光熱効果の協奏的作用による温度応答性高分子ゲル微粒子のマイクロパターン形成2018

    • Author(s)
      東海林 竜也, 出口 光宏, 麻生 隆彬, 松村 有里子, 加藤 郁也, 村越 敬, 坪井 泰之
    • Organizer
      2018年光化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 水/ヘキサン界面における金属・半導体ナノ結晶の効率的光捕捉2018

    • Author(s)
      山西 大樹, 仲 翔太, 東海林 竜也, 小山 晟矢, 亀山 達矢, 鳥本 司, 坪井 泰之
    • Organizer
      2018年光化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 半導体ナノ構造を利用した蛍光標識水溶性高分子鎖の光捕捉と分光測定2018

    • Author(s)
      永井 達也, 東海林 竜也, Saulius Juodkazis, Denver Linklater, 坪井 泰之
    • Organizer
      日本分析化学会第12回近畿支部平成夏季セミナー
    • Related Report
      2018 Research-status Report
  • [Presentation] 液/液界面光ピンセットを用いた金属・半導体ナノ粒子の同時光捕捉への試み2018

    • Author(s)
      山西 大樹, 仲 翔太, 東海林 竜也, 小山 晟矢, 亀山 達矢, 鳥本 司, 坪井 泰之
    • Organizer
      日本分析化学会第12回近畿支部平成夏季セミナー
    • Related Report
      2018 Research-status Report
  • [Presentation] 液液界面を利用した光マニピュレーション法の開発:LiLiI光ピンセット2018

    • Author(s)
      東海林 竜也
    • Organizer
      第39回光化学若手の会
    • Related Report
      2018 Research-status Report
  • [Presentation] 光圧により形成したポリ(N-イソプロピルアクリルアミド) 微粒子の顕微ラマン分光分析:分子量依存性の解明2018

    • Author(s)
      東海林 竜也, 藤原 華代, 松本 充央, 麻生 隆彬, 西山 聖, 堀邊 英夫, 坪井 泰之
    • Organizer
      第78回分析化学討論会
    • Related Report
      2018 Research-status Report
  • [Remarks] 大阪市立大学 理学部 化学科 先端分析化学研究室

    • URL

      http://www.sci.osaka-cu.ac.jp/chem/advanachem/index.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 東海林竜也 個人ページ

    • URL

      http://tshoji.com/

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

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