| Project/Area Number |
18K14281
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 35020:Polymer materials-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
Kosuke Kuroda 金沢大学, 生命理工学系, 准教授 (10748891)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | イオン液体 / 甘草 / 漢方 / ゲル / 双性イオン液体 / グリチルリチン酸 / セルロース / バイオマス |
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| Outline of Final Research Achievements |
Gels containing medicinal ingredients of licorice were formed by dissolving into a biocompatible zwitterionic cellulose solvent and successive precipitation. The licorice gels gradually released glycyrrhizic acid, the main medicinal ingredient of licorice, within 3 h. Although the licorice gels were mechanically weak, gel strength was improved just by adding cellulose during the preparation of the gels.
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| Academic Significance and Societal Importance of the Research Achievements |
低毒性なセルロース溶媒であるliquid zwitterionを用いて、薬用植物である甘草を溶解・析出させるのみで、薬効成分を含む甘草ゲルを作製した。これまでに薬用植物から、その成分を含むゲルを直接的に作ることはできなかった。ゲルを直接作製できることで有効成分を失わずに成形できること、その成分の徐放をおこなうこと、塗布薬にすることなどが可能となった。
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