| Project/Area Number |
18K14284
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 35020:Polymer materials-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 再生医療 / 三次元組織構築 / ヒドロゲル / 自在変形 / 適時分解 / 分子間相互作用 / 形状記憶 / 三次元組織 / バイオマテリアル |
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| Outline of Final Research Achievements |
In this two-year research, we aimed to develop a new scaffold material for three-dimensional tissue construction: a hydrogel material capable of free deformation, shape memory and degradation after use in the presence of cells. In the first year, the material design of the hydrogel as a base material was carried out, and a shape memory material was successfully developed using sugar as a mild chemical stimulus. In the second year, we optimized the design of materials with free-deformability, cytocompatibility, and degradability. We also succeeded in culturing cells on the materials while free-deforming the material and degrading it after culturing cells under cytocompatible conditions. This allowed us to propose a new material design that would serve as a foundation for the construction of a three-dimensional structure using shape-morphing materials.
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| Academic Significance and Societal Importance of the Research Achievements |
再生医療・組織工学分野では、細胞を立体的に配置した三次元組織を構築するために、足場材料をできるだけ短時間で正確に造形し、適切なタイミングで分解することが求められる。現在の主流である積層造形法では造形に時間がかかり、サイズに制限があった。そこで本研究では、自在に変形し一時形状を固定可能な材料を用いて「折り紙」式に三次元組織を形成し、形成後に材料を分解することで三次元組織を得る「形状記憶造形」を提案し、そのための第一歩として基盤となる足場材料の開発に取り組んだ。これが実現すれば、生体外での人工臓器・組織構築法の新たな選択肢となり、社会に対する大きな波及効果が見込まれる。
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