| Project/Area Number |
18K14407
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | homocarnosine / GABA / skeletal muscle / muscle regeneration / satellite cell / sarcopenia / carnosine / Homocarnosine / Carnosine / Skeletal muscle / Muscle regeneration / Satellite cells |
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| Outline of Final Research Achievements |
This study showed that dietary GABA is a great strategy to induce endogenous homocarnosine synthesis in skeletal muscles. However, dietary GABA is highly fed into a degradation pathway rather than fed into the homocarnosine synthesis. Thus, high doses of GABA intake is required to increase muscular homocarnosine levels. To solve the problem, inhibitors of GABA degradation efficiently increased blood GABA levels and muscular homocarnosine levels. The findings suggest that dietary homocarnosine with GABA or GABA-degrading inhibitors may be a new method to enhance the efficiency of increasing imidazole peptides in the muscles. we found that homocarnosine and its analogs decrease satellite cell susceptibility to early cell death upon activation, suggesting positive effects of homocarnosine on muscle regeneration. This study provides a strong foundation for the research on new roles of homocarnosine and carnosine in muscle regeneration to build up healthy muscles and to prevent sarcopenia.
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| Academic Significance and Societal Importance of the Research Achievements |
This study provides the new strategy to induce endogenous homocarnosine synthesis in the muscles and new mechanisms in regulating muscle regeneration. The findings will lead to the development of functional foods for building healthy muscles and preventing sarcopenia in both young and aging people.
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