The role of the novel sex steroid membrane receptor GPR30 on metabolic homeostasis.
Project/Area Number |
18K14414
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 38050:Food sciences-related
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Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
Ohue-Kitano Ryuji 東京農工大学, (連合)農学研究科(研究院), 特任講師 (90791583)
|
Project Period (FY) |
2018-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 腸内細菌代謝物 / エクオール / GPR30 / 代謝性疾患 / 大豆イソフラボン / 臓器連関 |
Outline of Final Research Achievements |
The present study provided the first evidence that GPR30, a novel receptor for estrogen on the plasma membrane, is involved in the regulation of lipid metabolism during diet-induced obesity. GPR30 might contribute to the suppression of lipid absorption from the intestinal tract , and these were depended on gender-specific. These findings could contribute to developing novel effective therapeutic strategies, and future basic and clinical research elucidating the pathophysiological significance of GPR30 will reveal for new avenues for preemptive medicine for obesity and metabolic diseases.
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Academic Significance and Societal Importance of the Research Achievements |
これまで肥満症や糖尿病などの代謝性疾患におけるエストロゲンの新規細胞膜上受容体GPR30の病態生理学意義は不明であったが、本研究にて、腸管のGPR30が脂質代謝調節に関与する可能性が明らかにされた。従来のエストロゲン受容体ERを介した脂質代謝改善作用に加え、本研究より明らかになったGPR30もまた、脂質異常症の新たな治療標的分子となり得る。これらの成果は、性ホルモンが代謝機能調節に関与することを示しており、今後、GPR30を標的とした新規治療薬創出だけでなく、大豆イソフラボンやエクオール等を含めた高機能性食品の開発を通じて、代謝性疾患の新たな予防・治療戦略の確立へと繋がることが期待される。
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice2020
Author(s)
Kimura I, Miyamoto J, Ohue-Kitano R, Watanabe K, Yamada T, Onuki M, Aoki R, Isobe Y, Kashihara D, Inoue D, Inaba A, Takamura Y, Taira S, Kumaki S, Watanabe M, Ito M, Nakagawa F, Irie J, Kakuta H, Shinohara M, Iwatsuki K, Tsujimoto G, Ohno H, Arita M, Itoh H, Hase K.
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Journal Title
Science
Volume: 367
Issue: 6481
Pages: 8429-8429
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions2019
Author(s)
Miyamoto J, Ohue-Kitano R, Mukouyama H, Nishida A, Watanabe K, Igarashi M, Irie J, Tsujimoto G, Satoh-Asahara N, Itoh H, Kimura I
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Journal Title
Proc Natl Acad Sci USA
Volume: 116
Issue: 47
Pages: 23813-23821
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of serum myostatin in the association between hyperinsulinemia and muscle atrophy in Japanese obese patients.2018
Author(s)
Tanaka M, Masuda S, Yamakage H, Inoue T, Ohue-Kitano R, Yokota S, Kusakabe T, Wada H, Sanada K, Ishii K, Hasegawa K, Shimatsu A, Satoh-Asahara N.
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Journal Title
Diabetes Res Clin Pract.
Volume: 142
Pages: 195-202
DOI
Related Report
Peer Reviewed / Open Access
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