| Project/Area Number |
18K14420
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | メタボローム解析 / 脂肪細胞 / 白色脂肪細胞の褐色化 / 肥満 |
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| Outline of Final Research Achievements |
Obesity is a recognized risk factor for serious disorders. Therefore, avoidance of obesity helps prevent serious lifestyle diseases. In this study, we investigated the mechanism of browning adipose tissue.
We showed that induction of browning adipose tissue in murine was markedly changed metabolism in inguinal adipose tissue using metabolome analysis. Furthermore, we found that amino acid, carbohydrate, and nucleic acid-associated metabolites were changed, particularly in inguinal adipose tissue.
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| Academic Significance and Societal Importance of the Research Achievements |
脂肪細胞はエネルギーの貯蔵を一つの役割とする白色脂肪細胞だけでなく、積極的にエネルギー代謝を促す褐色脂肪細胞や褐色化様脂肪細胞等、多様なタイプが存在することが知られる一方、それぞれの関連性については不明確な部分が多く残されている。本研究では、白色脂肪細胞が褐色化様脂肪細胞に変遷する過程において、アミノ酸、糖、核酸関連に分類される代謝物が特に変動することを見出し、白色脂肪細胞が褐色化様脂肪細胞に変遷するメカニズム解明の一助となる知見を得ることができた。
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