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Examining cancer biology from the aspect of breed specificity in dogs.

Research Project

Project/Area Number 18K14581
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionThe University of Tokyo

Principal Investigator

Tsuboi Masaya  東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (20721963)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords疫学 / 腫瘍 / 獣医学 / 犬種特異性 / 比較腫瘍学 / イヌゲノム / 獣医病理学 / がん微小環境
Outline of Final Research Achievements

In dogs, specific tumors tend to occur in specific breeds. We hypothesized that comparative analysis of breed-specific tumors would allow us to explore the underlying mechanisms of cancer development. Therefore, we conducted epidemiological surveys and investigated the breeds of dogs with a high incidence of tumors. Using the diagnostic database of the Laboratory of Veterinary Pathology at the University of Tokyo and medical information from the Veterinary Medical Center, the University of Tokyo, we investigated the breed specificity of canine tumor diseases. We found that, in addition to previously known findings, the frequency of tumors was significantly higher in certain small dog breeds, including miniature dachshunds.

Academic Significance and Societal Importance of the Research Achievements

本研究を通じて最も興味深かったのは、抽出された好発腫瘍疾患の数が犬種によって顕著に異なっていた点である。例えば、ミニチュア・ダックスフンドにおいて悪性黒色腫、肛門嚢腺癌、軟骨肉腫、前立腺癌などの腫瘍疾患が多く抽出された一方で、トイ・プードルに好発する腫瘍疾患は極めて少なかった。これらはいずれも国内の飼育頭数が多い犬種だが、腫瘍の発生率に大きな違いがあり、犬種の遺伝的特性が腫瘍罹患率に深く関与している可能性が示唆された。このような犬種の違いを更に踏み込んで比較することで、「癌になりやすさ」に関する新たな知見が得られると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2020 2019 2018 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 9 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Phase I/II Clinical Trial of the Anti-Podoplanin Monoclonal Antibody Therapy in Dogs with Malignant Melanoma2020

    • Author(s)
      Kamoto Satoshi、Shinada Masahiro、Kato Daiki、Yoshimoto Sho、Ikeda Namiko、Tsuboi Masaya、Yoshitake Ryohei、Eto Shotaro、Hashimoto Yuko、Takahashi Yosuke、Chambers James、Uchida Kazuyuki、Kaneko Mika K.、Fujita Naoki、Nishimura Ryohei、Kato Yukinari、Nakagawa Takayuki
    • Journal Title

      Cells

      Volume: 9 Issue: 11 Pages: 2529-2529

    • DOI

      10.3390/cells9112529

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PDPN Is Expressed in Various Types of Canine Tumors and Its Silencing Induces Apoptosis and Cell Cycle Arrest in Canine Malignant Melanoma2020

    • Author(s)
      Shinada Masahiro、Kato Daiki、Kamoto Satoshi、Yoshimoto Sho、Tsuboi Masaya、Yoshitake Ryohei、Eto Shotaro、Ikeda Namiko、Saeki Kohei、Hashimoto Yuko、Takahashi Yosuke、Chambers James、Uchida Kazuyuki、Kaneko Mika K.、Fujita Naoki、Nishimura Ryohei、Kato Yukinari、Nakagawa Takayuki
    • Journal Title

      Cells

      Volume: 9 Issue: 5 Pages: 1136-1136

    • DOI

      10.3390/cells9051136

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer2020

    • Author(s)
      YOSHIMOTO Sho、KATO Daiki、KAMOTO Satoshi、YAMAMOTO Kie、TSUBOI Masaya、SHINADA Masahiro、IKEDA Namiko、TANAKA Yuiko、YOSHITAKE Ryohei、ETO Shotaro、SAEKI Kohei、CHAMBERS James、HASHIMOTO Yuko、UCHIDA Kazuyuki、NISHIMURA Ryohei、NAKAGAWA Takayuki
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Issue: 6 Pages: 804-808

    • DOI

      10.1292/jvms.20-0026

    • NAID

      130007863921

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Variations in ATP7B in cats with primary copper-associated hepatopathy.2019

    • Author(s)
      Asada H, Chambers JK, Kojima M, Goto-Koshino Y, Kanagawa T, Yokoyama N, Tsuboi M, Uchida K, Tsujimoto H, Ohno K
    • Journal Title

      J Feline Med Surg

      Volume: - Issue: 8 Pages: 753-759

    • DOI

      10.1177/1098612x19884763

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical evaluation of HER2 expression in canine thyroid carcinoma2019

    • Author(s)
      Yoshimoto Sho、Kato Daiki、Kamoto Satoshi、Yamamoto Kie、Tsuboi Masaya、Shinada Masahiro、Ikeda Namiko、Tanaka Yuiko、Yoshitake Ryohei、Eto Shotaro、Saeki Kohei、Chambers James、Kinoshita Ryohei、Uchida Kazuyuki、Nishimura Ryohei、Nakagawa Takayuki
    • Journal Title

      Heliyon

      Volume: 5 Issue: 7 Pages: e02004-e02004

    • DOI

      10.1016/j.heliyon.2019.e02004

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrospective study of canine cutaneous tumors in Japan, 2008?20172019

    • Author(s)
      KOK Mun Keong、CHAMBERS James K.、TSUBOI Masaya、NISHIMURA Ryohei、TSUJIMOTO Hajime、UCHIDA Kazuyuki、NAKAYAMA Hiroyuki
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 8 Pages: 1133-1143

    • DOI

      10.1292/jvms.19-0248

    • NAID

      130007695246

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-tumor effects of the histone deacetylase inhibitor vorinostat on canine urothelial carcinoma cells2019

    • Author(s)
      Eto Shotaro、Saeki Kohei、Yoshitake Ryohei、Yoshimoto Sho、Shinada Masahiro、Ikeda Namiko、Kamoto Satoshi、Tanaka Yuiko、Kato Daiki、Maeda Shingo、Tsuboi Masaya、Chambers James、Uchida Kazuyuki、Nishimura Ryohei、Nakagawa Takayuki
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 6 Pages: 0218382-0218382

    • DOI

      10.1371/journal.pone.0218382

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of canine X-chromosome inactivation pattern analysis for the detection of cell clonality by incorporating the examination of the SLIT and NTRK-like family member 4 (SLITRK4) gene.2019

    • Author(s)
      Tomita A, Mochizuki H, Tsuboi M, Ogura I, Igarashi H, Goto-Koshino Y, Takahashi M, Ohmi A, Tomiyasu H, Ohno K, Nakagawa T, Uchida K, Nishimura R, Tsujimoto H
    • Journal Title

      Res Vet Sci

      Volume: 125 Pages: 170-175

    • DOI

      10.1016/j.rvsc.2019.06.004

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of human epidermal growth factor receptor 2 overexpression in canine anal sac gland carcinoma2019

    • Author(s)
      YOSHIMOTO Sho、KATO Daiki、KAMOTO Satoshi、YAMAMOTO Kie、TSUBOI Masaya、SHINADA Masahiro、IKEDA Namiko、TANAKA Yuiko、YOSHITAKE Ryohei、ETO Shotaro、SAEKI Kohei、CHAMBERS James Kenn、KINOSHITA Ryohei、UCHIDA Kazuyuki、NISHIMURA Ryohei、NAKAGAWA Takayuki
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 7 Pages: 1034-1039

    • DOI

      10.1292/jvms.19-0019

    • NAID

      130007680267

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of HER2 Expression in Canine Urothelial Carcinoma of the Urinary Bladder2019

    • Author(s)
      Tsuboi Masaya、Sakai Kosei、Maeda Shingo、Chambers James K.、Yonezawa Tomohiro、Matsuki Naoaki、Uchida Kazuyuki、Nakayama Hiroyuki
    • Journal Title

      Veterinary Pathology

      Volume: 56 Issue: 3 Pages: 369-376

    • DOI

      10.1177/0300985818817024

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sarcomatoid mesothelioma of tunica vaginalis testis in the right scrotum of a dog2018

    • Author(s)
      SON Nguyen V.、CHAMBERS James K.、SHIGA Takanori、KISHIMOTO Takuya E.、KIKUHARA Shotaro、SAEKI Kohei、FUJIWARA Reina、TSUBOI Masaya、NISHIMURA Ryohei、UCHIDA Kazuyuki、NAKAYAMA Hiroyuki
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 7 Pages: 1125-1128

    • DOI

      10.1292/jvms.18-0186

    • NAID

      130007404166

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple acquired portosystemic shunts secondary to primary hypoplasia of the portal vein in a cat2018

    • Author(s)
      SUGIMOTO Satoko、MAEDA Shingo、TSUBOI Masaya、SAEKI Kohei、CHAMBERS James K.、YONEZAWA Tomohiro、FUKUSHIMA Kenjiro、FUJIWARA Reina、UCHIDA Kazuyuki、TSUJIMOTO Hajime、MATSUKI Naoaki、OHNO Koichi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 6 Pages: 874-877

    • DOI

      10.1292/jvms.17-0648

    • NAID

      130007384664

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq2018

    • Author(s)
      Maeda Shingo、Tomiyasu Hirotaka、Tsuboi Masaya、Inoue Akiko、Ishihara Genki、Uchikai Takao、Chambers James K.、Uchida Kazuyuki、Yonezawa Tomohiro、Matsuki Naoaki
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 472-472

    • DOI

      10.1186/s12885-018-4409-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 東京大学動物医療センターにおける犬9,803例の疾病調査(2013-2018年)2020

    • Author(s)
      坪井誠也、中山裕之
    • Organizer
      第16回日本獣医内科学アカデミー学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 犬の腫瘍疾患の犬種特異性に関する疫学解析2020

    • Author(s)
      坪井誠也、中山裕之
    • Organizer
      第7回日本獣医病理学専門家協会(JCVP)学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 東京大学動物医療センターにおける犬9,803例の疾病調査(2013-2018年)2020

    • Author(s)
      坪井誠也、中山裕之
    • Organizer
      第16回獣医内科学アカデミー
    • Related Report
      2019 Research-status Report
  • [Presentation] 犬の腫瘍疾患の犬種特異性に関する疫学解析2020

    • Author(s)
      坪井誠也、中山裕之
    • Organizer
      第7回日本獣医病理専門家協会学術集会
    • Related Report
      2019 Research-status Report
  • [Remarks] 研究成果【Researchmap】

    • URL

      https://researchmap.jp/masayatsuboi/published_papers

    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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