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The relationship between plasma concentrations gut hormones and milk production and health of dairy cows.

Research Project

Project/Area Number 18K14593
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionRakuno Gakuen University

Principal Investigator

Fukumori Rika  酪農学園大学, 獣医学群, 准教授 (60721694)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsGLP-1 / GLP-2 / インスリン感受性 / 乳牛 / 乳生産 / 周産期疾病 / 酪酸 / エンドトキシン / 消化管炎症 / 消化管ホルモン / 消化 / ルーメンアシドーシス / 炎症 / インスリン / 栄養管理 / 分娩移行期
Outline of Final Research Achievements

Plasma concentrations of gut hormones in cows with any perinatal diseases (displaced placenta, clinical ketosis, retained placenta or hypocalcemia) 3 weeks after calving were not different with healthy cows in the close-up period (2 to 14 d before calving). On the other hand, cows with perinatal diseases had higher blood NEFA concentration and BCS, and lower rumen fill score and insulin sensitivity (RQUICKI). Furthermore, for the purpose of early adaptation of high grain feed in the lactating period, we examined feeding sodium butyrate to cows. Then feeding sodium butyrate increased plasma concentration of GLP-2, feed digestibility, and feed efficiency of dairy cows.

Academic Significance and Societal Importance of the Research Achievements

消化管ホルモンによる飼料への適応および代謝に及ぼす効果を明らかにした。乾乳期の代謝変化は周産期疾病に直結すると考えらるが、本研究から消化管ホルモン変化の関連性については捉えることが出来なかった。一方で、酪酸塩のような消化管ホルモン分泌を調節する栄養素の補給によって飼料消化率などの消化管機能に影響を与えることが明らかとなった。本研究の酪酸補給試験は、泌乳最盛期の乳牛で実施したが、乾乳期に給与し分娩前のホルモン分泌を調整することで泌乳や健全性への効果が期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] University of Alberta(カナダ)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Evaluation of relationship between ruminal pH and the proportion of de novo fatty acids in milk2021

    • Author(s)
      Rika Fukumori, Shi Weina, Shin Oikawa, Masahito Oba
    • Journal Title

      JDS communications

      Volume: **

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of butyrate supplementation on blood glucagon-like peptide-2 concentration and gastrointestinal functions of lactating dairy cows fed diets differing in starch content2020

    • Author(s)
      Fukumori R., Oba M., Izumi K., Otsuka M., Suzuki K., Gondaira S., Higuchi H, Oikawa S.
    • Journal Title

      Journal of Dairy Science

      Volume: 103 Issue: 4 Pages: 3656-3667

    • DOI

      10.3168/jds.2019-17677

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum paraoxonase-1 activity in tail and mammary veins of ketotic dairy cows.2020

    • Author(s)
      Fukumori R., Elsayed HK., Oba M., Tachibana Y., Nakada K., Oikawa S.
    • Journal Title

      Canadian Journal of Veterinary Research

      Volume: 84 Pages: 79-81

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of butyrate supplementation on the productivity of lactating dairy cows fed diets differing in starch content.2019

    • Author(s)
      Izumi K., Fukumori R., Oikawa S., Oba M.
    • Journal Title

      Journal of Dairy Science

      Volume: 102 Issue: 12 Pages: 11051-11056

    • DOI

      10.3168/jds.2019-17113

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 乳牛における酪酸塩の補給がSARA誘導時の炎症反応に及ぼす影響2019

    • Author(s)
      勝田遥香, 福森理加, 泉賢一, 大場真人, 大塚まりな, 鈴木一由, 及川伸
    • Organizer
      第162回日本獣医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 泌乳牛における飼料中デンプン含量の違いと酪酸サプリメント給与の有無が血中GLP-2濃度 と全消化管消化率に及ぼす影響2019

    • Author(s)
      山口峻太郎, 福森理加, 泉賢一, 大場真人, 及川伸
    • Organizer
      第162回日本獣医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effects of butyrate supplementation on productivity of lactating dairy cows fed diets differing in starch content2019

    • Author(s)
      Izumi K, Fukumori R, Oikawa S, Oba M
    • Organizer
      2019 ADSA annual meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of butyrate supplementation on blood glucagon-like peptide-2 concentration and gastrointestinal function in lactating dairy cows fed diets differing in starch content2019

    • Author(s)
      Fukumori R, Izumi K, Oikasa S, Oba M
    • Organizer
      2019 ADSA annual meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of butyrate supplementation on blood glucagon-like peptide-2 concentration and gastrointestinal function in lactating dairy cows fed diets differing in starch content2019

    • Author(s)
      Fukumori R., Izumi K., Oikawa S., Oba M
    • Organizer
      ADSA 2019 annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of butyrate supplementation on productivity of lactating dairy cows fed diets differing in starch content.2019

    • Author(s)
      Izumi K., Fukuori R., Oikawa S., Oba M.
    • Organizer
      ADSA 2019 annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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