| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The susceptibility of heartland bandavirus (HRTV) to type I interferon knockout mice was examined, and a novel lethal HRTV infection model was established.
In this study, the pathogenesis of survived mice and dead mice were compared following HRTV infection. The pathogenesis was compared based on the differences in clinical signs including hematology values and blood chemistry parameters, the levels of HRTV RNA in tissues, and the levels of cytokines and chemokines in blood of HRTV infected mice. This is the first study which analyzed chronological changes in pathology of HRTV in mice precisely.
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