| Project/Area Number |
18K14622
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 43010:Molecular biology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kishi Yusuke 東京大学, 大学院薬学系研究科(薬学部), 講師 (00645236)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経幹細胞 / クロマチン / Hmga2 / Plag1 / ポリコーム |
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| Outline of Final Research Achievements |
Most of the neurons, the most important cell types in the brain, are produced from neural stem cells during development. In the early stages of development, neural stem cells increase their number by self-renewal, but at a certain point, they begin to produce neurons. The timing of this fate change should be strictly regulated because it determines the number of neurons that are subsequently produced. However, the regulatory mechanism has been unknown. In this study, we found that the upregulation of Hmga2, a chromatin-regulating factor, during the transition from expansion to neurogenic phases regulates the gene expression pattern of neural stem cells and promotes fate switching.
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| Academic Significance and Societal Importance of the Research Achievements |
神経幹細胞の増殖期からニューロン分化期への運命転換の異常は、成体脳のニューロンやその他の細胞の数の異常につながる。実際に、この運命転換の異常が自閉症などの神経発達障害の原因の一つであると考えられている。
本研究ではこの運命転換のメカニズムとしてHmga2による制御が重要であることを明らかにした。そのため、本研究をもとに神経幹細胞の運命転換のメカニズム、ひいてはヒトの神経発達障害の理解につながると期待される。
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