| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Outline of Final Research Achievements |
β-barrel membrane proteins localised on the mitochondrial outer membrane is essential for transport of small molecules and mitochondrial functions . The SAM complex embeds these β-barrel membrane proteins into the membrane. We determined the cryo-EM structures of the SAM complex and the SAM-Mdm10 supercomplex, and elucidated the substrate exchange mechanism by the SAM complex. This study was published in Nature. Moreover, we have successfully determined the cryo-EM structure of the SAM complex in the process of embedding the substrate protein into the membrane and also clarified a part of the molecular mechanism.
|
