| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Notch signaling regulates various cell differentiation in multi-cellular organisms and its defects cause serious diseases such as cancer or neurodegeneration. Whereas the intracellular mechanisms controlling Notch signaling has well-established, little was understood about the controls received from outside the cell.
We discovered that Drosophila pecanex (pcx) was specifically essential for the ER morphogenesis within hemocytes. We also found that when pcx mutations occur in hemocytes, they newly acquire an ability to secrete Notch signaling inhibitors.
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