Analysis of peroxisomal membrane proteins
| Project/Area Number |
18K14736
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 44030:Plant molecular biology and physiology-related
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| Research Institution | Konan University |
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Principal Investigator |
Junpei Takagi 甲南大学, 理工学部, 特任研究助教 (80740331)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ペルオキシソーム / オルガネラ / 選別輸送 / シロイヌナズナ / peroxisome / endoplasmic reticulum |
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| Outline of Final Research Achievements |
Peroxisomes are organelles that is involved in various metabolic reactions. Peroxisome membrane proteins are responsible for maintaining peroxisome homeostasis. However, in plants, the selective transport mechanism of peroxisomal membrane proteins is not well understood. In this study, we performed live cell imaging analysis of various peroxisomal membrane proteins and found that peroxisomal matrix proteins are gradually accumulated in the lumen of preperoxisomal compartment-like structure to form mature peroxisomes.
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| Academic Significance and Societal Importance of the Research Achievements |
ペルオキシソームは環境変化に応じて，分裂，増殖したり，逆に分解を受けたりすることが知られている．植物においてペルオキシソームの分裂機構や分解機構については明らかになっている一方で，ペルオキシソームの成長・新規形成機構についてはほとんど明らかになっていない．本研究によってペルオキシソーム形成機構の一端に迫ることができた．将来的には，本研究の成果を環境変化に応答したペルオキシソームのダイナミクスの解明につなげていきたい．
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Report
(3 results)
Research Products
(10 results)
