Population genetics and molecular evolution of sex chromosome turnover

• Project/Area Number: 18K14766
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 45020:Evolutionary biology-related
• Research Institution: Kyoto University (2019-2021); Nihon University (2018)
• Principal Investigator: Katsura Yukako 京都大学, 霊長類研究所, 助教 (00624727)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 性染色体 / ゲノム解析 / 遺伝子発現解析 / ゲノム比較 / 無尾両生類 / 分子進化 / AI / 精巣発現遺伝子 / トランスクリプトーム / ツチガエル / トランスポゾン / 精巣 / 適応進化 / ゲノム / ターンオーバー / 集団遺伝 / 機能的制約

Outline of Final Research Achievements

To present a genetic model of sex chromosome turnover, we have researched focusing on the Japanese wrinkled frog, which has XY and ZW chromosomes in the same species. Although the genome of the Japanese wrinkled frog was not deciphered, the genome sequencing, assembling and annotation of the Japanese wrinkled frog were carried out based on the results of this research.

Academic Significance and Societal Importance of the Research Achievements

本研究では、性染色体のターンオーバーという生命現象の謎を明らかにするために、同一種内にXYとZW染色体をもつ稀有な生物種であるツチガエルに着目して研究を行っている。本研究成果により、ツチガエルのゲノムがCG頻度が高いという独自の特徴を持つことが明らかになった。そのゲノムの独自性がツチガエル 独自の性染色体進化に関与している可能性が示唆された。

Research Products

• [Int'l Joint Research] テンプル大学/ペンシルヴァニア州立大学(米国)
• [Int'l Joint Research] テンプル大学(米国)
• [Journal Article] Comparative genomics of Glandirana rugosa using unsupervised AI reveals a high CG frequency (2021)
  • Author(s): Katsura Y, Ikemura T, Kajitani R, Toyoda A, Itoh T, Ogata M, Miura I, Wada K, Wada Y, and Satta Y
  • Journal Title: Life Science Alliance Volume: - Issue: 5 Pages: e202000905-e202000905
  • DOI: 10.26508/lsa.202000905
  • NAID: 120007153083
  • Peer Reviewed / Open Access
• [Journal Article] Complex intragene deletion leads to oculocutaneous albinism in tanuki (Japanese raccoon dog) (2020)
  • Author(s): Mae Yuji、Nagara Kenji、Miyazaki Manabu、Katsura Yukako、Enomoto Yuki、Koga Akihiko
  • Journal Title: Genome Volume: 63 Issue: 10 Pages: 517-523
  • DOI: 10.1139/gen-2020-0049
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneity of synonymous substitution rates in the Xenopus frog genome. (2020)
  • Author(s): *Lau, Q., Igawa, T., Ogino, H., Katsura, Y., Ikemura, T. and Satta, Y.
  • Journal Title: PLoS One Volume: 15 Issue: 8 Pages: 2241-2242
  • DOI: 10.1371/journal.pone.0236515
  • NAID: 120007159972
  • Peer Reviewed / Open Access
• [Journal Article] The reproducibility of an inferred tree and the diploidization of gene segregation after genome duplication (2020)
  • Author(s): Katsura Yukako、Nei Masatoshi
  • Journal Title: Genome Biology and Evolution Volume: 12 Issue: 2 Pages: 3792-3796
  • DOI: 10.1093/gbe/evz272
  • NAID: 120007153082
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evolutionary Medicine of Retroviruses in the Human Genome (2019)
  • Author(s): Katsura Yukako、Asai Satoshi
  • Journal Title: The American Journal of the Medical Sciences Volume: 358 Issue: 6 Pages: 384-388
  • DOI: 10.1016/j.amjms.2019.09.007
  • Peer Reviewed
• [Presentation] ADAPTIVE EVOLUTION AND FUNCTIONAL DIFFERENTIATION OF TESTIS EXPRESSION GENES IN THERIA (2019)
  • Author(s): Yukako Katsura
  • Organizer: SMBE 2019
  • Int'l Joint Research
• [Presentation] Adaptive evolution and functional differentiation of testis expression genes in Theria (2019)
  • Author(s): Yukako Katsura
  • Organizer: ESEB 2019
  • Int'l Joint Research