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Population genetics and molecular evolution of sex chromosome turnover

Research Project

Project/Area Number 18K14766
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 45020:Evolutionary biology-related
Research InstitutionKyoto University (2019-2021)
Nihon University (2018)

Principal Investigator

Katsura Yukako  京都大学, 霊長類研究所, 助教 (00624727)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords性染色体 / ゲノム解析 / 遺伝子発現解析 / ゲノム比較 / 無尾両生類 / 分子進化 / AI / 精巣発現遺伝子 / トランスクリプトーム / ツチガエル / トランスポゾン / 精巣 / 適応進化 / ゲノム / ターンオーバー / 集団遺伝 / 機能的制約
Outline of Final Research Achievements

To present a genetic model of sex chromosome turnover, we have researched focusing on the Japanese wrinkled frog, which has XY and ZW chromosomes in the same species. Although the genome of the Japanese wrinkled frog was not deciphered, the genome sequencing, assembling and annotation of the Japanese wrinkled frog were carried out based on the results of this research.

Academic Significance and Societal Importance of the Research Achievements

本研究では、性染色体のターンオーバーという生命現象の謎を明らかにするために、同一種内にXYとZW染色体をもつ稀有な生物種であるツチガエルに着目して研究を行っている。本研究成果により、ツチガエルのゲノムがCG頻度が高いという独自の特徴を持つことが明らかになった。そのゲノムの独自性がツチガエル 独自の性染色体進化に関与している可能性が示唆された。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] テンプル大学/ペンシルヴァニア州立大学(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] テンプル大学(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Comparative genomics of Glandirana rugosa using unsupervised AI reveals a high CG frequency2021

    • Author(s)
      Katsura Y, Ikemura T, Kajitani R, Toyoda A, Itoh T, Ogata M, Miura I, Wada K, Wada Y, and Satta Y
    • Journal Title

      Life Science Alliance

      Volume: - Issue: 5 Pages: e202000905-e202000905

    • DOI

      10.26508/lsa.202000905

    • NAID

      120007153083

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complex intragene deletion leads to oculocutaneous albinism in tanuki (Japanese raccoon dog)2020

    • Author(s)
      Mae Yuji、Nagara Kenji、Miyazaki Manabu、Katsura Yukako、Enomoto Yuki、Koga Akihiko
    • Journal Title

      Genome

      Volume: 63 Issue: 10 Pages: 517-523

    • DOI

      10.1139/gen-2020-0049

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity of synonymous substitution rates in the Xenopus frog genome.2020

    • Author(s)
      *Lau, Q., Igawa, T., Ogino, H., Katsura, Y., Ikemura, T. and Satta, Y.
    • Journal Title

      PLoS One

      Volume: 15 Issue: 8 Pages: 2241-2242

    • DOI

      10.1371/journal.pone.0236515

    • NAID

      120007159972

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The reproducibility of an inferred tree and the diploidization of gene segregation after genome duplication2020

    • Author(s)
      Katsura Yukako、Nei Masatoshi
    • Journal Title

      Genome Biology and Evolution

      Volume: 12 Issue: 2 Pages: 3792-3796

    • DOI

      10.1093/gbe/evz272

    • NAID

      120007153082

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolutionary Medicine of Retroviruses in the Human Genome2019

    • Author(s)
      Katsura Yukako、Asai Satoshi
    • Journal Title

      The American Journal of the Medical Sciences

      Volume: 358 Issue: 6 Pages: 384-388

    • DOI

      10.1016/j.amjms.2019.09.007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] ADAPTIVE EVOLUTION AND FUNCTIONAL DIFFERENTIATION OF TESTIS EXPRESSION GENES IN THERIA2019

    • Author(s)
      Yukako Katsura
    • Organizer
      SMBE 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Adaptive evolution and functional differentiation of testis expression genes in Theria2019

    • Author(s)
      Yukako Katsura
    • Organizer
      ESEB 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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