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The distribution and evolution of C-to-U RNA editing in mitochondria

Research Project

Project/Area Number 18K14783
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 45030:Biodiversity and systematics-related
Research InstitutionThe University of Tokyo (2020)
Institute of Physical and Chemical Research (2018-2019)

Principal Investigator

Nishimura Yuki  東京大学, 大学院理学系研究科(理学部), 特任助教 (20783012)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsミトコンドリアゲノム / 転写後修飾 / C-to-U RNAエディティング / DYW型PPRタンパク質 / 有中心粒太陽虫類 / ネコブカビ類 / RNAエディティング / DYWドメイン / PPRタンパク質 / C-to-U型RNAエディティング / 有孔虫類
Outline of Final Research Achievements

C-to-U RNA editing is posttranslational processing observed in the organelle of various eukaryotes including land plants. In this study, I newly indicated that phytomyxea and centrohelida harbor the C-to-U editing systems in their mitochondria by searching in the public database. The mitochondrial genome sequence of phytomyxea also supported the existence of C-to-U RNA editing. Further, I actually confirmed the C-to-U RNA editing in centrohelida mitochondria and discussed its evolution in centrohelida by analyzing the gene playing a central role in the editing.

Academic Significance and Societal Importance of the Research Achievements

本研究は未だ理解が不十分だと考えられるミトコンドリアゲノムの多様性について、転写後修飾という面から新たな知見をもたらしたという意義がある。様々な系統群でC-to-U RNAエディティングが行われていることが改めて示されたことは、本現象が多様な真核生物におけるミトコンドリアの進化と深く関連していることを示唆している。その一方で、有中心粒太陽虫類では遺伝子の縮退によってエディティングシステムが二次的に失われた可能性が示されたのは進化生物的に興味深いと言える。さらに本現象はターゲットとする塩基のみを高い特異性で置換するので、生物工学的分野に応用されるポテンシャルがある成果である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Division of functional roles for termite gut protists revealed by single-cell transcriptomes2020

    • Author(s)
      Nishimura Yuki、Otagiri Masato、Yuki Masahiro、Shimizu Michiru、Inoue Jun-ichi、Moriya Shigeharu、Ohkuma Moriya
    • Journal Title

      The ISME Journal

      Volume: 14 Issue: 10 Pages: 2449-2460

    • DOI

      10.1038/s41396-020-0698-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Genomes of Hemiarma marina and Leucocryptos marina Revised the Evolution of Cytochrome c Maturation in Cryptista2020

    • Author(s)
      Nishimura Yuki、Kume Keitaro、Sonehara Keito、Tanifuji Goro、Shiratori Takashi、Ishida Ken-ichiro、Hashimoto Tetsuo、Inagaki Yuji、Ohkuma Moriya
    • Journal Title

      Frontiers in Ecology and Evolution

      Volume: 8 Pages: 140-140

    • DOI

      10.3389/fevo.2020.00140

    • NAID

      120007132656

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Horizontally-acquired genetic elements in the mitochondrial genome of a centrohelid Marophrys sp. SRT127.2019

    • Author(s)
      Yuki Nishimura, Takashi Shiratori, Ken-ichiro Ishida, Tetsuo Hashimoto, Moriya Ohkuma, Yuji Inagaki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 4850-4850

    • DOI

      10.1038/s41598-019-41238-6

    • NAID

      120007128095

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 有中心粒太陽虫類におけるミトコンドリアゲノムの比較解析2019

    • Author(s)
      西村祐貴, 佐藤渚, 白鳥峻志, 石田健一郎, 橋本哲男, 稲垣祐司, 大熊盛也
    • Organizer
      日本微生物資源学会第26回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 日本進化学会第21回大会2019

    • Author(s)
      西村祐貴、 佐藤渚、石谷佳之、白鳥峻志、石田健一郎、 橋本哲男、稲垣祐司, 大熊盛也
    • Organizer
      Distribution of plant-type mitochondrial C-to-U RNA editing in diverse eukaryotes
    • Related Report
      2019 Research-status Report
  • [Presentation] Re-exploration of the protein performing plant-type C-to-U RNA editing in diverse2019

    • Author(s)
      Yuki Nishimura, Nagisa Sato, Yoshiyuki Ishitani, Takashi Shiratori, Ken-ichiro Ishida, Tetsuo Hashimoto, Yuji Inagaki, Moriya Ohkuma
    • Organizer
      The 14th International Colloquim in Endocytobiology and Symbiosis
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヤマトシロアリ腸内に共生する原生生物の多様性と機能の解析2019

    • Author(s)
      西村祐貴、佐藤渚、大熊盛也
    • Organizer
      日本微生物生態学会第33回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 難培養性原生生物におけるシングルセルトランスクリプトーム:シロアリ共生原生生物をモデルとして2019

    • Author(s)
      西村祐貴、小田切正人、雪真弘、守屋繁春、大熊盛也
    • Organizer
      第13回日本ゲノム微生物学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] シロアリ腸内から分離された新規乳酸菌、Lactococcus reticulitermitis2018

    • Author(s)
      雪真弘、坂本光央、西村祐貴、大熊盛也
    • Organizer
      日本微生物資源学会第25回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] シングルセルゲノム・トランスクリプトームによるシロアリ共生微生物の機能解析2018

    • Author(s)
      西村祐貴
    • Organizer
      つくば藻類・プロティストフォーラム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Orphan protistology, accelerating in JAPAN2018

    • Author(s)
      Takashi Shiratori, Akinori Yabuki, Euki Yazaki, Yuki Nishimura, Moriya Ohkuma, Katsunori Fujikura, Tetsuo Hashimoto, Yuji Inagaki, Ken-ichiro Ishida
    • Organizer
      Joint Meeting of the Japan Society of Protistology and the Korean Society of Protozoologists
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Single cell transcriptome analyses of the symbiotic protists in termite gut2018

    • Author(s)
      Yuki Nishimura, Masato Otagiri, Masahiro Yuki, Michiru Shimizu, Nagisa Sato, Shigeharu Moriya, Moriya Ohkuma
    • Organizer
      日本微生物生態学会第32回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Single cell transcriptome analyses of the symbiotic protists in wood-feeding termites2018

    • Author(s)
      Yuki Nishimura, Masato Otagiri, Masahiro Yuki, Michiru Shimizu, Nagisa Sato, Shigeharu Moriya, Moriya Ohkuma
    • Organizer
      17th International Symposium on Microbial Ecology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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