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Mechanisms of multimodal sensory integration and decision making in Drosophila higher brain centers

Research Project

Project/Area Number 18K14813
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionKanazawa University

Principal Investigator

Takayanagi-Kiya Seika  金沢大学, 生命理工学系, 研究協力員 (40793196)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords神経科学 / 性行動 / 初期応答遺伝子 / 即初期遺伝子 / 神経科科学
Outline of Final Research Achievements

Animals continuosly make decisions based on sensory information they receive from the environment. In the current study, I aimed to investigate the neural basis of this decision-making process by using sexual behavior of the fruit fly Drosophila melanogaster as a model. Here I focused on a cluster of neurons termed aSP2 (which we previously reported as a cluster activated when males exhibit courtship), located in the higher order brain region of males, which receives multimodal sensory information. aSP2-silenced males were not able to sustain courtship towards a female, suggesting that aSP2 is involved in the decision-making process of whether or not to continue courting, and/or the regulation of courtship vigor. In addition, I found that the activity level of aSP2 neurons changes when a male touches a female by his front leg.

Academic Significance and Societal Importance of the Research Achievements

ショウジョウバエの脳高次中枢に存在するaSP2神経は雄で構成細胞数が多く、発達した雌雄差のある神経回路であることは知られていたが、その性行動における機能は不明であった。本研究はaSP2神経が雌由来の感覚情報に応答し、雄の性行動モチベーション維持に関わることを初めて示した。これは昆虫の脳における行動決定機構の一端を明らかにするものである。昆虫における感覚情報統合と、性行動制御の詳細がさらに解明されれば、将来的には昆虫の産業的利用の拡大や新たな害虫防除法の開発に貢献すると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2019 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Activity-dependent visualization and control of neural circuits for courtship behavior in the fly Drosophila melanogaster.2019

    • Author(s)
      Seika Takayanagi-Kiya and Taketoshi Kiya
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 116 Issue: 12 Pages: 5715-5720

    • DOI

      10.1073/pnas.1814628116

    • NAID

      120006605143

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 即初期遺伝子stripeを利用した神経回路の可視化と操作による、ショウジョウバエ雄の求愛行動に関わる神経基盤の解析2019

    • Author(s)
      高柳-木矢 星歌、塩谷 捺美、西内 巧、岩見 雅史、木矢 剛智
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Remarks] 昆虫の生得的行動を生み出す神経回路の新しい解析技術を確立!

    • URL

      https://www.kanazawa-u.ac.jp/rd/65392

    • Related Report
      2020 Annual Research Report 2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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