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Identify the genes and glia epigenetically affected by social isolation

Research Project

Project/Area Number 18K14814
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionOsaka University

Principal Investigator

Noriyoshi Usui  大阪大学, 医学系研究科, 特任助教(常勤) (00784076)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords社会性 / 環境要因 / 幼少期 / ストレス / エピゲノム / トランスクリプトーム / グリア / ニューロン / 社会環境 / 発達 / エピジェネティク / エピジェネティクス / 神経細胞 / グリア細胞 / 自閉スペクトラム症 / 遺伝子発現
Outline of Final Research Achievements

The aim of this study was to understand the mechanism of poor social environment in childhood that adversely affects brain development and sociality acquisition. Mice that underwent social isolation during childhood showed impaired social behavior and increased anxiety-like behavior, and decreased numbers of neurons and microglia in the frontal cortex. Gene expression analysis identified genes involved in transcriptional regulation, stress response, and synaptic function, and revealed that these genes are involved in autism spectrum disorders and stress-related diseases. In addition, the most significantly altered gene S15 knockout mouse showed an impairment in social behavior, uncovering a part of the mechanism by which the social environment in childhood influences brain development and acquisition of sociality.

Academic Significance and Societal Importance of the Research Achievements

本研究により、幼少期の社会環境が脳の脳と行動に与える影響が明らかになった。幼少期の社会環境は環境要因であることから、子どもの生育環境を整えることによって適切な脳の発達や社会性の形成、ストレスの軽減や予防などが期待できると考える。本研究での遺伝子発現や脳組織における知見は自閉スペクトラム症のモデルマウスの知見と類似することからも、前頭皮質の神経細胞のシナプス形成やミクログリアの適切な発達が社会性に関わる神経基盤に繋がるとが示唆された。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (22 results)

All 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (10 results) (of which Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (7 results)

  • [Int'l Joint Research] UT Southwestern Medical Center(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] UT Southwestern Medical Center(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Accelerated evolution of oligodendrocytes in the human brain2019

    • Author(s)
      Berto Stefano*、Mendizabal Isabel*、Usui Noriyoshi*、Toriumi Kazuya*、Chatterjee Paramita、Douglas Connor、Tamminga Carol A.、Preuss Todd M.、Yi Soojin V.、Konopka Genevieve [*Co-first authors]
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 48 Pages: 24334-24342

    • DOI

      10.1073/pnas.1907982116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cell type-specific epigenetic links to schizophrenia risk in the brain2019

    • Author(s)
      Mendizabal Isabel*、Berto Stefano*、Usui Noriyoshi*、Toriumi Kazuya*、Chatterjee Paramita、Douglas Connor、Huh Iksoo、Jeong Hyeonsoo、Layman Thomas、Tamminga Carol A.、Preuss Todd M.、Konopka Genevieve、Yi Soojin V.
    • Journal Title

      Genome Biology

      Volume: 20 Issue: 1 Pages: 135-135

    • DOI

      10.1186/s13059-019-1747-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 子どもの社会性コミュニケーション能力形成の分子メカニズムの解明2018

    • Author(s)
      臼井紀好
    • Organizer
      福井大学「ライフサイクル医学」推進学部長裁量経費成果発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] Foxp1 regulation of neonatal vocal communication via cortical development2018

    • Author(s)
      臼井紀好
    • Organizer
      福井大学第9回優秀論文発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] 自閉症における神経基盤の解明を目指して2018

    • Author(s)
      臼井紀好
    • Organizer
      第7回大阪大学神経難病フォーラム
    • Related Report
      2018 Research-status Report
  • [Presentation] Approaching autism from molecules2018

    • Author(s)
      臼井紀好
    • Organizer
      第40回日本生物学的精神医学会・第61回日本神経化学会大会合同年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脳回路形成における自閉症原因遺伝子FOXP1の役割2018

    • Author(s)
      臼井紀好、島田昌一
    • Organizer
      第94回日本解剖学会近畿支部学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヒトの脳進化と脳機能障害2018

    • Author(s)
      臼井紀好
    • Organizer
      第8回自閉症学研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 社会性の形成に関わる神経基盤の探索2018

    • Author(s)
      臼井紀好、松﨑秀夫、小山佳久、中村雪子、近藤誠、島田昌一
    • Organizer
      第1回医学系研究科-産業科学研究所懇話会
    • Related Report
      2018 Research-status Report
  • [Presentation] 潰瘍性大腸炎の新しい治療薬の開発2018

    • Author(s)
      小山佳久、小林悠輝、近藤誠、臼井紀好、小林光、島田昌一
    • Organizer
      第124回日本解剖学会総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 5-HT3受容体を介する新たな抗うつメカニズム2018

    • Author(s)
      近藤誠、小山佳久、中村雪子、臼井紀好、島田昌一
    • Organizer
      第124回日本解剖学会総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 社会性の形成に関わる神経基盤の探索2018

    • Author(s)
      臼井紀好、松﨑秀夫、小山佳久、中村雪子、近藤誠、島田昌一
    • Organizer
      第124回日本解剖学会総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Book] ストレス科学研究34巻2019

    • Author(s)
      臼井 紀好
    • Total Pages
      3
    • Publisher
      公益財団法人パブリックヘルスリサーチセンター
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 記憶障害の予防又は治療剤2019

    • Inventor(s)
      島田昌一、近藤誠、小山佳久、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Holder
      島田昌一、近藤誠、小山佳久、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 自閉スペクトラム症の予防又は治療剤2019

    • Inventor(s)
      島田昌一、臼井紀好、小山佳久、近藤誠、小林光、小林悠輝
    • Industrial Property Rights Holder
      島田昌一、臼井紀好、小山佳久、近藤誠、小林光、小林悠輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 関節炎の予防又は治療剤2019

    • Inventor(s)
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Holder
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 内臓不快感の予防又は治療剤2019

    • Inventor(s)
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Holder
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 脊髄損傷後の障害もしくは症状の予防又は治療剤2019

    • Inventor(s)
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Holder
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 糖尿病の予防又は治療剤2019

    • Inventor(s)
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Holder
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 虚血性脳血管障害の予防又は治療剤2019

    • Inventor(s)
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Holder
      島田昌一、小山佳久、近藤誠、臼井紀好、小林光、小林悠輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2023-12-25  

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