| Project/Area Number |
18K14815
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Chiba University |
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Principal Investigator |
HIRAYAMA Yuri 千葉大学, 大学院医学研究院, 助教 (30732804)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ミクログリア / 脳梗塞 / VNUT / ATP / 脳虚血 / グリア細胞 |
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| Outline of Final Research Achievements |
ATP, which is the universal energy currency of life, is released into the extracellular space and acts as a neurotransmitter. ATP is known to be increased in response to transient brain ischemia, but whether this ATP increase is beneficial or harmful to cerebral ischemic injury is controversial, and a mechanism underlying the ATP increase is unknown. Vesicular nucleotide transporter (VNUT), a transporter responsible for vesicular storage of ATP, plays an important role in purinergic signaling in various physiological and pathological phenomena. Here, we show that the ATP exocytosis via VNUT in microglia, a type of glial cell, contributes to neuroprotection against cerebral ischemic injury.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでの脳虚血障害治療薬の標的は神経細胞であった。本研究により、グリア細胞（ミクログリア）はプリン作動性シグナルを介して、脳虚血障害に対して保護作用をもたらすことが明らかとなった。これにより、全く新しい脳卒中治療戦略に繋がる基礎データを蓄積することができた。
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