| Project/Area Number |
18K14818
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 46010:Neuroscience-general-related
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Goto Akihiro 京都大学, 医学研究科, 特定助教 (10741332)
|
|---|
| Project Period (FY) |
2018-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | LTP / CALI / 記憶の形成 / cofilin / Cofilin / sLTP / SuperNova |
|---|
| Outline of Final Research Achievements |
NMDA receptor dependent LTP is a phenomenon of memory formation at cell level. However, it is difficult for previous technique to examine when and where LTP takes place during memory formation in a brain. Therefore, we developed CALI technique to examine time window of LTP during memory formation. We found that LTP was induced in hippocampus right after memory formation. Furthermore, LTP was induced again during sleep and 2 hours after memory formation. This finding is expected to contribute to understanding mechanisms of memory formation at cell level.
|
| Academic Significance and Societal Importance of the Research Achievements |
LTPは記憶に重要であることが知られているが、記憶形成の過程で実際にいつどこでLTPが誘導されているかはわかっていなかった。したがって、LTPの時間枠を検討できる当研究は記憶研究において画期的なツールとなる。
記憶の形成過程において、記憶がどのように長期的に定着するかは多くの人々の関心事であり、本研究の知見は認知症の予防・治療の基盤に繋がる可能性も秘めており社会に大きく貢献できると期待できる。
|
