Remodeling of excitatory and inhibitory networks in the motor cortex
| Project/Area Number |
18K14844
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 46020:Anatomy and histopathology of nervous system-related
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
Sohn Jaerin 生理学研究所, 基盤神経科学研究領域, 特任研究員 (40780333)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 運動学習 / 運動野 / シナプス可塑性 / 電子顕微鏡 / 錐体細胞 / 光学・電子顕微鏡相関解析 / 興奮性シナプス / 抑制性シナプス / ATUM-SEM法 / 光学・電子顕微鏡相関観察法 / 学習 / 興奮性ニューロン / 抑制性ニューロン / 免疫組織化学 |
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| Outline of Final Research Achievements |
While motor learning affords novel motor skills to animals, neuronal circuit in the motor cortex is dynamically rearranged. We investigated this network remodeling morphologically, by observation in vivo of spine dynamics on dendrites in the motor cortex combined with characterization of presynaptic axon terminals. We revealed that motor learning enhanced spine dynamics, i.e. spine formation and elimination. In addition, temporal dynamics were different between corticocortical and thalamocortical synapses. Our findings suggest that corticocortical and thalamocortical pathways contribute differently to animal's motor skill acquisition.
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| Academic Significance and Societal Importance of the Research Achievements |
動物の学習における大脳皮質の役割を知るには、学習時に変化するニューロン同士の結合パターンを知る必要がある。本研究により形態学的解析を通じて運動学習中に起こる運動野神経回路の変化を網羅的に調べることが可能になった。光学顕微鏡による入出力の描写や、電子顕微鏡を用いた微細構造解析により、運動学習によるシナプス結合の時間的特異性が明らかとなった。これにより大脳皮質が果たす学習での役割の解明に一歩前進することができた。
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Report
(4 results)
Research Products
(23 results)
