| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Japanese encephalitis virus (JEV) is widely distributed to Asia, causing serious acute encephalitis. Although the mechanism of anti-JEV responses have been investigated by various studies, much remains unknown.
The aim of this study was to identify host factors involving to resistance to JEV infection by gene knockout screen using CRISPR/Cas9 system or gene activation screen using CRISPR/dCAS9 system. As a result of two genome wide screens, multiple host factors involved in JEV infection were identified.
|
