• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Targetable regulatory mechanism in placental syncytialization and endocrine function for treating the pregnancy complication

Research Project

Project/Area Number 18K14926
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 47040:Pharmacology-related
Research InstitutionKeio University

Principal Investigator

Noguchi Saki  慶應義塾大学, 薬学部(芝共立), 助教 (10803661)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords胎盤 / 胎盤関門 / miRNA / 合胞体化 / 栄養膜細胞 / マイクロRNA
Outline of Final Research Achievements

We indicated that miR-126, an angiogenic micro RNA enhances the expression of placental genes, such as syncytin-1/-2, fusogenic molecule for placenta barrier formation and SLC22A11, an estrogen precursor transporter at placental barrier, in trophoblast model cells. Thus, our results raised the possibility that the aberrant expression of miR-126 in preeclamptic placenta reflects placental barrier disfunction. Furthermore, the present study revealed that LIN28A, an RNA binding protein related trophoblast stemness, is a direct target of miR-126 in the trophoblast model cells. Therefore, these results suggested the new role of miR-126 in placental trophoblast.

Academic Significance and Societal Importance of the Research Achievements

miR-126が胎盤における関門形成と内分泌機能に重要な分子の発現に影響することが示唆されたことから、miR-126が胎盤機能を反映する指標の一つとなる可能性を示すことができた。血管内皮における機能が主に解析されてきたmiRNAについて、胎盤における役割の解明に資する結果を得た。miR-126標的経路に対する解析は、妊娠高血圧腎症およびこれを原因とする胎児発育不全において胎児環境を正常化する治療の開発につながると期待できる。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] 妊娠による生理学的変化と薬物動態2020

    • Author(s)
      西村 友宏、野口 幸希
    • Journal Title

      月刊薬事

      Volume: 62 Pages: 33-43

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake.2019

    • Author(s)
      Nishimura T, Sano Y, Takahashi Y, Noguchi S, Uchida Y, Takagi A, Tanaka T, Katakura S, Nakashima E, Tachikawa M, Maruyama T, Terasaki T, Tomi M.
    • Journal Title

      J Pharm Sci.

      Volume: 108(12) Issue: 12 Pages: 3917-3922

    • DOI

      10.1016/j.xphs.2019.09.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] miR-126が栄養膜モデルJEG-3細胞における合胞体化促進因子の発現に与える影響2019

    • Author(s)
      潘曉楽、野口幸希、安藤美鈴、竹村千尋、西村友宏、登美斉俊
    • Organizer
      日本薬剤学会第34年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス栄養膜幹細胞3次元培養系における関門機能分子の発現誘導2019

    • Author(s)
      木林由佳、野口幸希、田辺美那子、齋藤義正、西村友宏、登美斉俊
    • Organizer
      日本薬剤学会第34年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The role of OAT4, a bidirectional organic anion transporter, on drug distribution and excretion in humans2019

    • Author(s)
      Saki Noguchi
    • Organizer
      3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of SLC22A11 promoter for placental OAT4 expression2019

    • Author(s)
      Naomi Fukazawa, Saki Noguchi, Kanako Furugori, Tomohiro Nishimura, Masatoshi Tomi
    • Organizer
      3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SUBSTRATE RECOGNITION AND CHLORIDE ION DEPENDENT TRANSPORT OF ANGIOTHENSIN II RECEPTOR BLOCKERS BY OAT42019

    • Author(s)
      Saki Noguchi, Moeko Tobita, Hayumi Atsuta, Rika Kimura, Ayaka Fukumoto, Tomohiro Nishimura, and Masatoshi Tomi
    • Organizer
      12TH INTERNATIONAL ISSX MEETING
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胎盤特異的なヒトSLC22A11 発現における転写制御の解析2019

    • Author(s)
      野口幸希、古郡加奈子、深澤尚美、西村友宏、登美斉俊
    • Organizer
      第41回生体膜と薬物の相互作用シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血漿中アミノ酸濃度変動がpregabalinの脳移行に与える影響2019

    • Author(s)
      野口幸希、高橋優、西村友宏、登美斉俊
    • Organizer
      日本薬物動態学会第34回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] OAT4/OAT3発現MDCK細胞を介したolmesartan経細胞輸送におけるOAT4の役割2019

    • Author(s)
      舟橋和毅、野口幸希、西村友宏、登美斉俊
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヒト栄養膜由来JEG-3細胞の分化過程におけるmiR-126の役割2019

    • Author(s)
      潘暁楽、野口幸希、安藤美鈴、竹村 千尋、西村友宏、登美斉俊
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヒトSLC22A11の胎盤特異的プロモーター領域の解析2019

    • Author(s)
      野口幸希、古郡加奈子、深澤尚美、西村友宏、中島恵美、登美斉俊
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヒト絨毛癌由来JEG-3細胞の分化過程におけるmiR-126発現がLIN28A発現に与える影響2018

    • Author(s)
      潘暁楽、野口幸希、安藤美鈴、竹村 千尋、西村友宏、登美斉俊
    • Organizer
      第3回トランスポーター研究会関東部会
    • Related Report
      2018 Research-status Report
  • [Presentation] Transcriptional regulatory element for the placental expression of organic anion transporter 42018

    • Author(s)
      Noguchi S,Furugori K,Nishimura T,Nakashima E,Tomi M
    • Organizer
      International Federation of Placenta Associations (IFPA) 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 有機アニオン系薬物トランスポーターOAT4を介したアンジオテンシンII受容体拮抗薬の輸送2018

    • Author(s)
      野口幸希、熱田萩弓、木村りか、飛田萌子、福本文香、西村友宏、登美斉俊
    • Organizer
      日本薬剤学会第33年会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi