| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To search for natural drugs that regulate BMP/Smad signaling, we screened 700 Myanmar plant extracts and 1496 Ryukyu arc plant extracts by reporter assay. As a result, Smad activity was observed in 29 Myanmar plant extracts and 26 Ryukyu Arc plant extracts. In the Myanmar plant, five flavonoids were isolated from the bark of the Oroxylum indicum (L.). In the Ryukyu Arc plant, forty polymethoxyflavonoids including 3 new compounds were isolated from the whole plants of Scutellaria rubropunctata. These compounds were examined for their Smad activity and effects on osteoblasts.
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