| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, the mechanism of metronidazole (MTZ)-induced encephalopathy was investigated focusing on the possibility that MTZ, with a substructure similar to thiamine, inhibits thiamine transporters to decrease thiamine uptake into the brain and induce the encephalopathy (“thiamine deficiency hypothesis”). The effects of MTZ near clinical concentrations on the cellular uptake and the transcellular transport of thiamine were investigated in vitro and the results suggested that MTZ may not inhibit the absorption of thiamine from the gastrointestinal tract and its transport into brain tissue. However, an increased cellular uptake of thiamine was detected with relatively high concentrations of MTZ.
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