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The potential role of FABP5 in hypothalamic tanycytes

Research Project

Project/Area Number 18K15000
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 48010:Anatomy-related
Research InstitutionTohoku University

Principal Investigator

Yasumoto Yuki  東北大学, 医学系研究科, 非常勤講師 (40779352)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脂肪酸結合タンパク質 / 視床下部 / タニサイト / 脂肪滴 / ミトコンドリア / 脂肪酸 / FABP5 / 脂肪酸代謝 / 脂肪酸結合タンパク質5
Outline of Final Research Achievements

Hypothalamic arcuate nucleus is an important brain part to sense the nutrient, such as amino acids, glucose and lipids. I revealed the localization of the FABP family (FABP 3, 5 and 7) in the hypothalamus by immunohistochemistry. The expression level of FABP7 in glia correlated with the number and size of lipid droplets. Also, FABP7 worked protectively to external-stress induced apoptosis. FABP5 expressed in tanycytes in the hypothalamus. FABP3 which has a high affinity to arachidonic acid expressed in the blood vessels and neurons in the hypothalamus. FABP3 KO mice showed the decrease of intake of arachidonic acid into the isolated blood vessels and neurons.

Academic Significance and Societal Importance of the Research Achievements

脂肪酸結合タンパク質の視床下部弓状核における発現は、サブタイプごとに異なっており、FABP7はグリアの脂肪滴の大きさや数の制御に関与し細胞保護に働くこと、FABP5は、FABP3は血管とニューロンにおけるアラキドン酸の取り込みに関与することをそれぞれ明らかにした。また、ミトコンドリア呼吸鎖複合体を構成するNdufs4は、細胞内ROSの産生やGnRHをはじめとする視床下部ホルモン分泌に関与していることが分かった。以上の結果は、視床下部を構成する各種細胞では、血液中の脂肪酸への細胞応答やミトコンドリア機能変化が、内分泌系や自律神経系の活動と密接に関連していることを示唆している。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation2019

    • Author(s)
      Islam Ariful、Kagawa Yoshiteru、Miyazaki Hirofumi、Shil Subrata Kumar、Umaru Banlanjo A.、Yasumoto Yuki、Yamamoto Yui、Owada Yuji
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 8 Pages: 5763-5779

    • DOI

      10.1007/s12035-019-1489-2

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

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