| Project/Area Number |
18K15006
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 48010:Anatomy-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
ISLAM Md.Nabiul 山口大学, 大学院医学系研究科, 助教 (80759671)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Motor neuron / Autonomic neuron / Neurodegeneration / Neuroprotection / Spinal cord / Brain stem / HAP1 / Motoneuron |
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| Outline of Final Research Achievements |
Huntingtin-associated protein 1 (HAP1) is a neural huntingtin interactor and being considered as a protective factor against neurodegenerative apoptosis in vitro. Here, we examined the spatio-temporal expression of HAP1 in spinal cord, brain stem and their associated muscles, using wild-type mice and motor-neuron-specific HAP1-TG mice that we genetically engineered using Cre-LoxP technology in our laboratory. HAP1 is abundantly expressed in the spinal sensory and autonomic neurons but completely lacking in motor neurons and their associated muscles, suggesting that the motor neurons due to lack of HAP1-protectivity, are more vulnerable to neurodegeneration. The outcome of our study may shed light on yet-to-be-uncovered new diagnostic or therapeutic applications for motor neuron diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
The outcome of our study may lead to create a motor neuron-degeneration-resistant-mice model in near future and will shed light on yet-to-be-uncovered new diagnostic or therapeutic applications for motor neuron diseases including ALS, Hirayama disease, spinal muscular atrophy and SBMA.
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