| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Recent aging studies have suggested that cellular senescence is deeply involved in individual aging. While cellular senescence in individuals functions as a cancer suppressor, the accumulation of senescent cells causes chronic inflammation in organs and tissues, leading to age-related diseases. Therefore, elucidation of the molecular mechanism that suppresses senescence has become an important issue in aging research. The purpose of this study was to clarify the molecular mechanism of inhibition of cellular senescence by a transcription factor ZHX3. Next-generation sequence analysis and knockout mouse analysis revealed that the transcription factor ZHX3 plays an important role in cellular senescence.
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