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Functional analysis of LPCAT3 in liver homeostasis and regeneration

Research Project

Project/Area Number 18K15074
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 49010:Pathological biochemistry-related
Research InstitutionNational Center for Global Health and Medicine

Principal Investigator

INAGAKI NATSUKO  国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 (00611419)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords肝臓 / リン脂質 / 多価不飽和脂肪酸 / リゾリン脂質アシル転移酵素 / 肝再生 / メタボローム / グリセロリン脂質 / PUFA / 再生 / 肝疾患 / アシル転移酵素 / 脂質 / LPCAT3 / 生体恒常性機構
Outline of Final Research Achievements

The liver has a remarkably high regenerative capacity that is regulated by several growth factors and signaling pathways working in a coordinated manner after liver resection to restore lost liver volume and function. Moreover, changes in membrane phospholipid composition have been reported during liver regeneration. However, the pathophysiological significance of these changes remains unknown. In this project, we focused on lysophosphatidylcholine acyltransferase 3 (LPCAT3), which incorporates arachidonic acid into lysophospholipids to produce phospholipids, and investigated whether qualitative and quantitative changes in membrane phospholipid composition might affect liver regeneration. Our study demonstrated that changes in membrane phospholipid composition allowed hepatocytes to prepare for the proliferation stage required for regeneration of liver tissue.

Academic Significance and Societal Importance of the Research Achievements

LPCAT3は、2008年に研究代表者の所属研究室で単離された酵素であり、その生理学的機能や病態形成に果たす役割に関しては未解明な部分が多い。肝再生の観点からLPCAT3の恒常性維持機構については、これまで国内外においても報告例がなく、本研究成果によりLPCAT3が肝切除後肝再生における肝細胞の増殖に関与することを示すことが出来た。この成果は将来的に新規治療法などの開発へと発展しうる可能性が期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) Book (2 results)

  • [Journal Article] Generation of mesothelial progenitor-like cells from mouse-induced pluripotent stem cells2019

    • Author(s)
      Inagaki NF*, Inagaki FF, Kokudo N, Miyajima A.
    • Journal Title

      FEBS Letters.

      Volume: 593 Issue: 4 Pages: 386-394

    • DOI

      10.1002/1873-3468.13325

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ω6系多価不飽和脂肪酸含有リン脂質による肝再生調節機構の解明2021

    • Author(s)
      稲垣奈都子、進藤英雄、清水孝雄
    • Organizer
      第20回 日本再生医療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アラキドン酸含有リン脂質による肝再生調節機構の解明2021

    • Author(s)
      稲垣奈都子、清水孝雄
    • Organizer
      第7回 肝臓と糖尿病・代謝研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アシル転移酵素LPCAT3の肝臓における役割の解明2018

    • Author(s)
      稲垣奈都子, 進藤英雄, 高橋佳一, 橋立智美, 浜野文三江, 徳岡涼美, 清水孝雄
    • Organizer
      第41回 分子生物学会
    • Related Report
      2018 Research-status Report
  • [Book] Advances in Stem Cell Biology - iPSCs Derived Progenitors2021

    • Author(s)
      Natsuko F Inagaki , Fuyuki Inagaki
    • Total Pages
      300
    • Publisher
      Elsevier
    • Related Report
      2020 Annual Research Report
  • [Book] Advances in Stem Cell Biology2020

    • Author(s)
      Natsuko F Inagaki, Fuyuki F Inagaki
    • Publisher
      Elsevier
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-12-25  

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