Clarification of cancer progression mechanism based on the movement of tumor cells infiltration

• Project/Area Number: 18K15080
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Osaka University
• Principal Investigator: Matsui Takahiro 大阪大学, 医学系研究科, 助教 (50747037)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生体イメージング / がん浸潤

Outline of Final Research Achievements

Although it has long been recognized that the characteristics of tumor cell dynamics are extremely important factors in the progression of malignant tumors, it has been difficult to obtain information on cell dynamics from conventional tissue specimens. In this study, we observed model animals using intravital imaging technology and visualized the dynamics of tumor cells during tumor growth and progression. As a result, we extracted the factors that can detect the tumor progression at an early stage and can be applied to the cancer tissue diagnosis in clinical medicine. Moreover, we found that the established evaluation system can be actually applied to human tissue samples.

Academic Significance and Societal Importance of the Research Achievements

悪性腫瘍（がん）の早期発見は現在の本邦の医療状況では最重要課題といえる課題であり、本研究で見出された成果の社会的意義は極めて大きい。また、病理学に立脚した基礎研究成果と光学イメージング技術との融合が、非常に大きな意義があることを示すものでもある。さらに現時点では国際的にも同様の報告例は未だなく、独自性の高い内容で学術的にも大きな意義がある。

Research Products

• [Journal Article] Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1. (2019)
  • Author(s): Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Matsui T, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko VV, Yamaoka K, Takeuchi T, Ishii M.
  • Journal Title: Nat Immunol. Volume: 20 Issue: 12 Pages: 1631-1643
  • DOI: 10.1038/s41590-019-0526-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A case report of granulomatous amoebic encephalitis by Group 1 Acanthamoeba genotype T18 diagnosed by the combination of morphological examination and genetic analysis (2018)
  • Author(s): Matsui Takahiro、Maeda Tetsuo、Kusakabe Shinsuke、Arita Hideyuki、Yagita Kenji、Morii Eiichi、Kanakura Yuzuru
  • Journal Title: Diagnostic Pathology Volume: 13 Issue: 1 Pages: 27-27
  • DOI: 10.1186/s13000-018-0706-z
  • Peer Reviewed / Open Access
• [Presentation] “切らない組織診断”－2光子励起イメージング技術を用いた低侵襲・迅速・定量的がん診断法の開発 (2018)
  • Author(s): 松井崇浩, 森正樹, 森井英一, 石井優
  • Organizer: 第107回日本病理学会総会
• [Presentation] 造血器腫瘍に対する同種骨髄移植後に発症した胸膜実質性線維弾性症の一剖検例 (2018)
  • Author(s): 松井崇浩, 金倉譲, 森井英一
  • Organizer: 第64回日本病理学会秋期特別総会