| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Bat mumps virus (bMuV), a novel paramyxovirus, was isolated from fruit bats in Zambia. Full-genome sequence analyses revealed bMuV was closely related to human mumps virus and they have 77% homology in nucleotide sequences. Genetic screening showed that 21% of the bats examined were positive for bMuV genome and the virus was frequently detected in spleens, kidneys, colons, and salivary glands. The findings suggested that bMuV may be transmitted through bat secreta such as saliva, urine, and feces. Mice, rats, hamsters, and guinea pigs challenged with bMuV through either of intranasally or intraperitoneal route did not show any apparent clinical signs. However, induction of bMuV-specific antibodies and viral growth in tissues, such as spleens, salivary glands, and colons, were observed, indicating that bMuV has a potential to infect mammalian hosts other than bats.
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