Analysis of interactions between virus and host factors regarding antigen presentation
Project/Area Number |
18K15175
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 49060:Virology-related
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
Seki Sayuri 国立感染症研究所, エイズ研究センター, 主任研究官 (70758325)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | ヒト免疫不全ウイルス / サル免疫不全ウイルス / 細胞傷害性T細胞 / 抗原提示 / 宿主因子 / HIV / MHC-I / ウイルスタンパク |
Outline of Final Research Achievements |
Induction of virus-specific cytotoxic T lymphocyte (CTL) responses has been shown to be important in controlling HIV infection. Optimization of antigens is necessary to induce virus-specific CTLs effectively. In the present study, target cells expressing Vif were killed by CTLs efficiently in the presence of Vif-APOBEC3G interaction. These results gave molecular level insight into reasonable design of HIV antigens.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究においては、宿主因子と相互作用を有するウイルス蛋白質が、固有のメカニズムによってエイズウイルス複製制御に結びつく有効なCTL抗原となりうる可能性が新しく見出された。宿主因子・ウイルス蛋白質・CTL反応それぞれの機構が繋がった学術的意義は大きい。また、本研究はHIV感染症の流行を抑えるための免疫反応誘導戦略を考える上で、より有効な抗原をデザインするための理論基盤の一部をなすため、社会的意義のある成果である。
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Fecal Microbiome Composition in Healthy Adults in Ghana2021
Author(s)
Parbie Prince Kofi、Mizutani Taketoshi、Ishizaka Aya、Kawana-Tachikawa Ai、Runtuwene Lucky Ronald、Seki Sayuri、Abana Christopher Zaab-Yen、Kushitor Dennis、Bonney Evelyn Yayra、Ofori Sampson Badu、Uematsu Satoshi、Imoto Seiya、Kimura Yasumasa、Kiyono Hiroshi、Ishikawa Koichi、Ampofo William Kwabena、Matano Tetsuro
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 74
Issue: 1
Pages: 42-47
DOI
NAID
ISSN
1344-6304, 1884-2836
Year and Date
2021-01-29
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Fecal bacterial profile in HIV associated gut microbial dysbiosis2019
Author(s)
Prince Kofi Parbie, Taketoshi Mizutani, Aya Ishizaka, Sayuri Seki, Christopher Zaab-Yen Abana, Dennis Kushitor, Evelyn Yayra Bonney, Sampson Badu Ofori, William Kwabena Ampofo, Koichi Ishikawa, Tetsuro Matano
Organizer
第67回日本ウイルス学会学術集会
Related Report
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[Presentation] Microbial dysbiosis and associated functional shifts in gut microbiome of HIV infected patients2019
Author(s)
Prince Kofi Parbie, Taketoshi Mizutani, Aya Ishizaka, Sayuri Seki, Christopher Zaab-Yen Abana, Dennis Kushitor, Evelyn Yayra Bonney, Sampson Badu Ofori, William Kwabena Ampofo, Koichi Ishikawa, Tetsuro Matano
Organizer
第33回日本エイズ学会学術集会
Related Report
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