| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Adenosine-to-inosine RNA editing catalyzed by ADAR1 is essential to prevent the recognition of endogenous dsRNA as non-self by MDA5. Although RNA editing is especially abundant in the thymus, its physiological role remains elusive. In this study, we revealed that T cell development requires coordinated regulation by ADAR1 via MDA5-dependent and -independent pathways. Furthermore, we found that T cell-specific deletion of ADAR1 in mice caused impaired negative selection to eliminate autoreactive T cells, leading to autoimmunity.
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