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Functional significance of TP53 mutation in vivo

Research Project

Project/Area Number 18K15207
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 50010:Tumor biology-related
Research InstitutionGifu University

Principal Investigator

Hatano Yuichiro  岐阜大学, 大学院医学系研究科, 助教 (10456543)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsがん関連遺伝子 / TP53 / 高異型度漿液性癌
Outline of Final Research Achievements

Here, to clarify the functional significance of TP53 mutation in in-vivo human carcinogenesis, genetic, clinical, and pathological analyses were performed in high-grade serous carcinoma of the female genital tract, which is a representative TP53-mutated cancer model. Although the aberrant patterns of p53 expression were closely associated with the mutation type of TP53, no clinical and pathological significance was observed in cancer cells over-expressing mutated p53. To elucidate the functional significance of the gain of function-type p53 mutant, further assessment based on each TP53 mutation type should be conducted.

Academic Significance and Societal Importance of the Research Achievements

高頻度に観察されるTP53遺伝子変異の機能的意義の解明は、がんの診断や治療の基盤となりうる。本研究では、TP53遺伝子の翻訳産物であるp53の異常発現パターンに注目して、TP53遺伝子変異が確定している高異型度漿液性癌の臨床病理学的特徴を解析した。変異型p53蛋白の発現と関連した特徴は同定できなかったが、TP53遺伝子変異パターンごとに症例を集積し、個別に解析することがTP53遺伝子変異の多様性の解明に繋がると考えられた。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 9 results) Presentation (2 results)

  • [Journal Article] Molecular Trajectory of BRCA1 and BRCA2 Mutations2020

    • Author(s)
      Hatano Y, Tamada M, Matsuo M, Hara A.
    • Journal Title

      Frontiers in Oncology

      Volume: 10 Pages: 361-361

    • DOI

      10.3389/fonc.2020.00361

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases2020

    • Author(s)
      Hara A, Niwa M, Noguchi K, Kanayama T, Niwa A, Matsuo M, Hatano Y, Tomita H.
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 3 Pages: 389-389

    • DOI

      10.3390/biom10030389

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Comprehensive Review of Ovarian Serous Carcinoma2019

    • Author(s)
      Hatano Y, Hatano K, Tamada M, Morishige KI, Tomita H, Yanai H, Hara A.
    • Journal Title

      Advances In Anatomic Pathology

      Volume: 26 Issue: 5 Pages: 329-339

    • DOI

      10.1097/pap.0000000000000243

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of a BAC transgenic mouse expressing Krt19-driven iCre recombinase in its digestive organs2019

    • Author(s)
      Kanayama Tomohiro、Tomita Hiroyuki、Binh Nguyen Huy、Hatano Yuichiro、Aoki Hitomi、Okada Hideshi、Hirata Akihiro、Fujihara Yoshitaka、Kunisada Takahiro、Hara Akira
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 8 Pages: e0220818-e0220818

    • DOI

      10.1371/journal.pone.0220818

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity in Colorectal Cancer Stem Cells2019

    • Author(s)
      Hirata Akihiro、Hatano Yuichiro、Niwa Masayuki、Hara Akira、Tomita Hiroyuki
    • Journal Title

      Cancer Prevention Research

      Volume: 12 Issue: 7 Pages: 413-420

    • DOI

      10.1158/1940-6207.capr-18-0482

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma2019

    • Author(s)
      Hara A, Kanayama T, Noguchi K, Niwa A, Miyai M, Kawaguchi M, Ishida K, Hatano Y, Niwa M, Tomita H.
    • Journal Title

      Journal of Oncology

      Volume: 2019 Pages: 2964783-2964783

    • DOI

      10.1155/2019/2964783

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity of Colon Cancer Stem Cells2019

    • Author(s)
      Hirata A, Hatano Y, Niwa M, Hara A, Tomita H.
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1139 Pages: 115-126

    • DOI

      10.1007/978-3-030-14366-4_7

    • ISBN
      9783030143657, 9783030143664
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-course analysis of cardiac and serum galectin-3 in viral myocarditis after an encephalomyocarditis virus inoculation2019

    • Author(s)
      Noguchi Kei、Tomita Hiroyuki、Kanayama Tomohiro、Niwa Ayumi、Hatano Yuichiro、Hoshi Masato、Sugie Shigeyuki、Okada Hideshi、Niwa Masayuki、Hara Akira
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 1 Pages: e0210971-e0210971

    • DOI

      10.1371/journal.pone.0210971

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-grade serous ovarian carcinoma with mucinous differentiation: report of a rare and unique case suggesting transition from the “SET” feature of high-grade serous carcinoma to the “STEM” feature2019

    • Author(s)
      Hatano Yuichiro、Tamada Maho、Asano Nami、Hayasaki Yoh、Tomita Hiroyuki、Morishige Ken-ichirou、Hara Akira
    • Journal Title

      Diagnostic Pathology

      Volume: 14 Issue: 1 Pages: 4-4

    • DOI

      10.1186/s13000-019-0781-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inchworm sign of endometrial cancer on diffusion-weighted MRI: radiology?pathology correlation2018

    • Author(s)
      Kawaguchi M.、Kato H.、Hatano Y.、Mizuno N.、Furui T.、Morishige K.、Hara A.、Goshima S.、Matsuo M.
    • Journal Title

      Clinical Radiology

      Volume: 73 Issue: 10 Pages: 907.e9-907.e14

    • DOI

      10.1016/j.crad.2018.05.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-grade serous carcinoma with discordant p53 signature: report of a case with new insight regarding high-grade serous carcinogenesis2018

    • Author(s)
      Hatano Yuichiro、Fukuda Shinya、Makino Hiroshi、Tomita Hiroyuki、Morishige Ken-ichirou、Hara Akira
    • Journal Title

      Diagnostic Pathology

      Volume: 13 Issue: 1 Pages: 24-24

    • DOI

      10.1186/s13000-018-0702-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 19-Gauge Histology Needle Versus a 19-Gauge Standard Needle in Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Solid Lesions: A Multicenter Randomized Comparison Study (GREATER Study)2018

    • Author(s)
      Iwashita Takuji、Nakai Yousuke、Mukai Tsuyoshi、Togawa Osamu、Matsubara Saburo、Hatano Yuichiro、Hara Akira、Tanaka Mariko、Shibahara Junji、Fukayama Masashi、Isayama Hiroyuki、Yasuda Ichiro
    • Journal Title

      Digestive Diseases and Sciences

      Volume: 63 Issue: 4 Pages: 1043-1051

    • DOI

      10.1007/s10620-018-4913-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical and Pathological Features of Vitelline Vasculitis2020

    • Author(s)
      Hatano Y, Tamada M, Matsuo M, Tomita H, Asano N, Hara A.
    • Organizer
      The 109th USCAP annual meeting. Los Angeles, USA, 2020.3.2
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高異型度漿液性癌におけるp53蛋白発現とTP53遺伝子変異の関連性2018

    • Author(s)
      福田 真也、波多野 裕一郎、金山 知弘、丹羽 亜弓、 野口 慶、富田 弘之、原 明
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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