| Project/Area Number |
18K15276
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Yuki Okinaka 滋賀医科大学, 医学部, 非常勤講師 (90780718)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌関連疲労 / メタボローム / 泌尿器癌 / サイトカイン / バイオマーカー / 疲労 |
|---|
| Outline of Final Research Achievements |
It became clear that fatigue in advanced urologic cancer patients treated with chemotherapy increased significantly after chemotherapy. In general blood / biochemical tests and cytokine measurement, which were generally used , no index was found to objectively evaluate fatigue, however, comprehensive metabolite measurements found metabolites suggestive of being associated with fatigue.Some of these metabolites were contained in the urea cycle, which was also associated with non-cancerous fatigue, and it was possible that the fatigue associated with chemotherapy was also common to non-cancerous fatigue.
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| Academic Significance and Societal Importance of the Research Achievements |
抗癌薬物治療中の疲労感に関して一般的に診療で用いる血液一般・生化学検査及びサイトカイン測定では明らかな疲労感を客観的に評価できる指標は認めなかった。しかし網羅的代謝物測定を行うことで、非癌性疲労の際に変動する代謝物と共通する代謝物を抗癌薬物治療中の患者においても認めた。こうした知見により今後抗癌薬物治療に関連する疲労感に関しても非癌性疲労での知見を応用することで客観的に評価可能な指標および新たな治療戦略へ繋がる可能性がある。
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