Exploration of biomarkers of the efficacy of trabectedin in soft tissue sarcoma

• Project/Area Number: 18K15303
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: The University of Tokyo
• Principal Investigator: Kobayashi Hiroshi 東京大学, 医学部附属病院, 助教 (20407951)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 悪性軟部腫瘍 / バイオマーカー / 骨軟部腫瘍

Outline of Final Research Achievements

There are several chemotherapy regimen to treat soft tissue sarcoma. Trabectedin is one of the drugs for advanced soft tissue sarcoma. It is important to reveal the biomarker to predict the efficacy of trabectedin. The purpose of this research was to elucidate the biomarker of trabectedin to predict the efficacy through genomic analysis of tumor specimens and mechanism of resistance to trabectedin. We identified several possible genomic biomarker, and will perform more analysis in the future.

Academic Significance and Societal Importance of the Research Achievements

悪性軟部腫瘍に対する化学療法薬の複数選択肢がある中で、そのバイオマーカーを同定することが求められている。本研究は進行例悪性軟部腫瘍に対して保険適応となっているトラベクテジンの奏効性を予測する指標を腫瘍の遺伝子解析を行うことで、同定することを目的とした。本研究の結果、効果予測の候補となる遺伝子が挙げられたためさらなる解析を行う予定である。

Research Products

• [Journal Article] Efficacy and safety of trabectedin for patients with unresectable and relapsed soft‐tissue sarcoma in Japan: A Japanese Musculoskeletal Oncology Group study (2019)
  • Author(s): Kobayashi Hiroshi、Iwata Shintaro、Wakamatsu Toru、Hayakawa Keiko、Yonemoto Tsukasa、Wasa Junji、Oka Hiroyuki、Ueda Takafumi、Tanaka Sakae
  • Journal Title: Cancer Volume: 126 Issue: 6 Pages: 1253-1263
  • DOI: 10.1002/cncr.32661
• [Journal Article] Reconstruction Using Frozen Autograft for Disseminated Phosphaturic Mesenchymal Tumor of the Humerus after a Pathological Fracture (2019)
  • Author(s): Kobayashi Hiroshi、Hirai Toshihide、Makise Naohiro、Ushiku Tetsuo、Ito Nobuaki、Koga Minae、Ikegami Masachika、Shinoda Yusuke、Akiyama Toru、Tanaka Sakae
  • Journal Title: Case Reports in Orthopedics Volume: 2019 Pages: 1-7
  • DOI: 10.1155/2019/3015675
• [Journal Article] Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations (2019)
  • Author(s): Tsuda Yusuke、Matsubara Daisuke (5th) etc
  • Journal Title: International Journal of Cancer Volume: 145 Issue: 12 Pages: 3276-3284
  • DOI: 10.1002/ijc.32421
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Body composition as a predictor of toxicity after treatment with eribulin for advanced soft tissue sarcoma (2018)
  • Author(s): Kobayashi Hiroshi、Okuma Tomotake、Oka Hiroyuki、Okajima Koichi、Ishibashi Yuki、Zhang Liuzhe、Hirai Toshihide、Ohki Takahiro、Tsuda Yusuke、Ikegami Masachika、Sawada Ryoko、Shinoda Yusuke、Akiyama Toru、Kawano Hirotaka、Goto Takahiro、Tanaka Sakae
  • Journal Title: International Journal of Clinical Oncology Volume: 24 Issue: 4 Pages: 437-444
  • DOI: 10.1007/s10147-018-1370-8
  • Peer Reviewed
• [Presentation] 日本人における軟部肉腫に対するトラベクテジンの有効性と安全性 (2019)
  • Author(s): 小林寛、岡敬之、岩田慎太郎、若松透、早川景子、和佐潤志、角永茂樹、箱崎道之、柳川天志、筑紫聡、米本司、田中栄、上田孝文
  • Organizer: 第５２回日本整形外科学会骨軟部腫瘍学術研究会
• [Presentation] 骨軟部腫瘍におけるクリニカルシーケンスの現状と今後の課題、シンポジウム (2019)
  • Author(s): 小林寛
  • Organizer: 第５２回日本整形外科学会骨軟部腫瘍学術研究会
• [Presentation] Chemotherapy for bone and soft tissue sarcoma -Realizing precision medicine- (2019)
  • Author(s): 小林寛
  • Organizer: 4th - Japan & Korea musculoskeletal oncology forum
  • Invited
• [Presentation] Infiltrative nature of tumor-induced osteomalacia lesions in bone: correlation between radiological and histopathological features (2019)
  • Author(s): Hiroshi Kobayashi, Naohiro Makise, Tetsuo Ushiku, Nobuaki Ito, Yuka Kinoshita, Yusuke Shinoda, Seiji Fukumoto, Sakae Tanaka
  • Organizer: RCOST
  • Int'l Joint Research