Epigenomic analysis of dedifferentiated liposarcoma

• Project/Area Number: 18K15328
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Keio University
• Principal Investigator: Asano Naofumi 慶應義塾大学, 医学部(信濃町), 講師 (10445299)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肉腫 / 脂肪肉腫 / 脱分化型脂肪肉腫 / DNAメチル化 / 脱メチル化剤 / 脱分化 / ゲノム / エピゲノム

Outline of Final Research Achievements

Dedifferentiated liposarcoma is a high-grade soft tissue sarcoma that predominantly affects in adults. In this study, we performed a comprehensive genomic DNA methylation analysis of well-differentiated and dedifferentiated liposarcomas. We found that DNA methylation of genes related to adipogenic differentiation may be involved in malignant transformation in highly malignant dedifferentiated liposarcomas. Our results suggest that demethylating agent therapy may be useful as a novel therapeutic strategy for dedifferentiated liposarcoma in the future.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、今後更なる前臨床研究が必須ではあるが、手術以外に有効な治療法が確立されていない、脱分化型脂肪肉腫の新規治療戦略となり得ることが期待される。

Research Products

• [Presentation] Epigenomic disruption of adipogenic regulators in dedifferentiated liposarcoma Short title: Epigenomic changes in liposarcoma (2019)
  • Author(s): Hironori Takamatsu, Naoko Hattori, Naofumi Asano, Naoko Iida, Akihiko Yoshida, Eisuke Kobayashi, Robert Nakayama, Morio Matsumoto, Masaya Nakamura, Akira Kawai, Toshikazu Ushijima
  • Organizer: American Association for Cancer Research (AACR) Annual Meeting 2019
  • Int'l Joint Research
• [Presentation] Epigenomic disruption of adipogenic regulators in dedifferentiated liposarcoma Short title: Epigenomic changes in liposarcoma (2019)
  • Author(s): Hironori Takamatsu, Naoko Hattori, Naofumi Asano, Naoko Iida, Akihiko Yoshida, Eisuke Kobayashi, Robert Nakayama, Morio Matsumoto, Masaya Nakamura, Akira Kawai, Toshikazu Ushijima
  • Organizer: AACR (American Association for Cancer Research) Annual Meeting 2019
  • Int'l Joint Research