Combination therapy of radioimmunotherapy and antifibrotic drug
| Project/Area Number |
18K15335
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Fujiwara Kentaro 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 博士研究員(任常) (80766907)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 放射免疫療法 / 線維芽細胞 / 抗体イメージング / 小分子化抗体 / PET / SPECT / 核医学 / 放射線医学 / 微小環境 |
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| Outline of Final Research Achievements |
Combination therapy of radioimmunotherapy (RIT) and antifibrotic agent for small cell lung cancer xenograft mice was performed in this study. The combination therapy group showed a higher therapeutic effect than RIT alone group.
Immuno-imaging study for gastric cancer xenograft mice was performed. We developed two CDH17-targeted immuno-imaging agents. These agents showed high accumulation of CDH17-positive xenografts and visualized the tumors in vivo study. These results were reported as two original journal articles.
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| Academic Significance and Societal Importance of the Research Achievements |
がん細胞を効率よく殺す治療法の組み合わせを検討するため、放射免疫療法と線維化阻害剤の併用治療の効果を評価した。併用による効果は限定的であったが、プロトコールの最適化により有効な治療法となり得る。
がんの転移を高い精度で診断することは、治療方針を決める上で極めて重要である。抗体イメージングは高精度な診断を実現できる手法の一つである。本研究で開発した２種類のプローブIn-111標識抗CDH17IgGとCu-64標識抗CDH17ミニボディは、胃がんのリンパ節転移を高精度に検出し、最適な治療方針を決定するための有用な診断薬となる可能性がある。
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] 64Cu-labeled minibody D2101 visualizes CDH17-positive gastric cancer xenografts with short waiting time2020
Author(s)
Kentaro Fujiwara, Hiroki Akiba, Atsushi B. Tsuji, Hitomi Sudo, Aya Sugyo, Kotaro Nagatsu, Ming-Rong Zhang, Hiroko Iwanari, Osamu Kusano-Arai, Shota Kudo, Chika Kikuchi, Kouhei Tsumoto, Toshimitsu Momose, Takao Hamakubo, Tatsuya Higashi
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Journal Title
Nuclear Medicine Communications
Volume: -
Related Report
Peer Reviewed / Open Access
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[Journal Article] 111In-labeled anti-cadherin17 antibody D2101 has potential as a noninvasive imaging pro be for diagnosing gastric cancer and lymph-node metastasis2019
Author(s)
Fujiwara K, *Tsuji A, Sudo H, Sugyo A, Akiba H, Iwanari H, Kusano-Arai O, Tsumoto K, Momose T, Hamakubo T, Higashi T
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Journal Title
Annals of Nuclear Medicine
Volume: 34
Issue: 1
Pages: 13-23
DOI
Related Report
Peer Reviewed / Open Access
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