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Elucidation of the pathophysiology of prefrontal cortex in patients with treatment-resistant depression using transcranial magnetic stimulation neurophysiology

Research Project

Project/Area Number 18K15375
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 51030:Pathophysiologic neuroscience-related
Research InstitutionKeio University

Principal Investigator

NODA Yoshihiro  慶應義塾大学, 医学部(信濃町), 特任准教授 (20807226)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Discontinued (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords治療抵抗性うつ病 / 経頭蓋磁気刺激法 / 高精度脳波計測 / TMS-EEG法 / 神経可塑性 / 経頭蓋磁気刺激(TMS) / 高精度脳波(EEG) / 治療抵抗性うつ病(TRD) / TMS誘発脳波(TEP) / 神経可塑性(neuroplasticity) / ニューロモデュレーション / GABA / グルタミン酸 / 磁気刺激誘発脳波
Outline of Final Research Achievements

In this study, 30 patients with medication-resistant depression were strictly enrolled in neurophysiological experiments using TMS combined with high-resolution EEG. In addition, age- and sex-matched 30 healthy controls with depression were recruited and TMS-EEG experiments were conducted. Specifically, GABA(A) receptor- mediated neurophysiological function, glutamate NMDA receptor-mediated neurophysiological function, and neuroplasticity in the dorsolateral prefrontal cortex (DLPFC) were measured with combined TMS-EEG method by applying short-interval intracortical inhibition (SICI), intracortical facilitation (ICF), and paired associative stimulation (PAS), respectively. As a result, it was suggested that glutamatergic excitatory function as indexed by ICF may be relatively elevated and neuroplastic function as indexed by PAS may be decreased in patients with treatment-resistant depression compared with healthy controls in the DLPFC.

Academic Significance and Societal Importance of the Research Achievements

治療抵抗性うつ病は、心理・社会・経済的損失が大きい病態群であるため、本病態の適切な診断と治療は当事者の社会機能の維持・社会復帰支援に貢献する可能性が極めて高い。今後はうつ病患者の前頭前野における神経可塑性を指標に層別化できるかどうかを評価していく方針である。本研究の知見や方法論を他の精神科的状態像にも応用することで、精神科臨床におけるより客観的な生物学的診断補助、精神科健診システムの開発、さらには神経生理指標を治療ターゲットとした新規rTMS療法の開発にも繋げてゆきたい。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (45 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (6 results) Journal Article (20 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 20 results,  Open Access: 7 results) Presentation (16 results) (of which Int'l Joint Research: 3 results,  Invited: 11 results) Remarks (3 results)

  • [Int'l Joint Research] Centre for Addiction and Mental Health/University of Toronto/University Health Network(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Aalto University School of Science(フィンランド)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] UC San Diego Health(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Monash University(オーストラリア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Centre forAddiction and Mental Health/Department of Psychiatry/University of Toronto(カナダ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Toronto/Department of Psychiatry/Centre for Addiction and Mental Health(カナダ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] TMS-EEG Research to Elucidate the Pathophysiological Neural Bases in Patients with Schizophrenia: A Systematic Review2021

    • Author(s)
      Li Xuemei、Honda Shiori、Nakajima Shinichiro、Wada Masataka、Yoshida Kazunari、Daskalakis Zafiris J.、Mimura Masaru、Noda Yoshihiro
    • Journal Title

      Journal of Personalized Medicine

      Volume: 11 Issue: 5 Pages: 388-388

    • DOI

      10.3390/jpm11050388

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potential Neurophysiological Mechanisms of 1Hz-TMS to the Right Prefrontal Cortex for Depression: An Exploratory TMS-EEG Study in Healthy Participants2021

    • Author(s)
      Noda Yoshihiro
    • Journal Title

      Journal of Personalized Medicine

      Volume: 11 Issue: 2 Pages: 68-68

    • DOI

      10.3390/jpm11020068

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients2021

    • Author(s)
      Noda Yoshihiro、Barr Mera S.、Zomorrodi Reza、Cash Robin F. H.、Lioumis Pantelis、Chen Robert、Daskalakis Zafiris J.、Blumberger Daniel M.
    • Journal Title

      Journal of Personalized Medicine

      Volume: 11 Issue: 1 Pages: 54-54

    • DOI

      10.3390/jpm11010054

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis2021

    • Author(s)
      Mimura Yu、Nishida Hana、Nakajima Shinichiro、Tsugawa Sakiko、Morita Shinji、Yoshida Kazunari、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Kurose Shin、Miyazaki Takahiro、Blumberger Daniel M.、Daskalakis Zafiris J.、Chen Robert、Mimura Masaru、Noda Yoshihiro
    • Journal Title

      Neuroscience & Biobehavioral Reviews

      Volume: 121 Pages: 47-59

    • DOI

      10.1016/j.neubiorev.2020.12.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects on Depression and Anxiety After Mid-Urethral Sling Surgery for Female Stress Urinary Incontinence2020

    • Author(s)
      Kinjo M, Masuda K, Nakamura Y, Taguchi S, Tambo M, Okegawa T, Fukuhara H.
    • Journal Title

      Res Rep Urol

      Volume: 19 Issue: 1 Pages: 495-501

    • DOI

      10.1017/s0033291720004729

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vagally Mediated Heart Rate Variability Is Associated With Executive Function Changes in Patients With Treatment‐Resistant Depression Following Magnetic Seizure Therapy2020

    • Author(s)
      Noda Yoshihiro、Knyahnytska Yuliya、Zomorrodi Reza、Downar Jonathan、Rajji Tarek K.、Daskalakis Zafiris J.、Blumberger Daniel M.
    • Journal Title

      Neuromodulation: Technology at the Neural Interface

      Volume: - Issue: 8 Pages: 100-110

    • DOI

      10.1111/ner.13262

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Socioeconomical transformation and mental health impact by the COVID-19’s ultimate VUCA era: Toward the New Normal, the New Japan, and the New World2020

    • Author(s)
      Noda Yoshihiro
    • Journal Title

      Asian Journal of Psychiatry

      Volume: 54 Pages: 102262-102262

    • DOI

      10.1016/j.ajp.2020.102262

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of delay discount alterations in addiction and psychiatric disorders: A systematic review of magnetic resonance imaging studies2020

    • Author(s)
      Noda Yoshihiro、Barr Mera S.、ElSalhy Muhammad、Masuda Fumi、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Tsugawa Sakiko、Miyazaki Takahiro、Nakajima Shinichiro、Mimura Masaru
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 99 Pages: 109822-109822

    • DOI

      10.1016/j.pnpbp.2019.109822

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Toward the establishment of neurophysiological indicators for neuropsychiatric disorders using transcranial magnetic stimulation‐evoked potentials: A systematic review2019

    • Author(s)
      Noda Yoshihiro
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 1 Pages: 12-34

    • DOI

      10.1111/pcn.12936

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The P300 event-related potential in bipolar disorder: A systematic review and meta-analysis2019

    • Author(s)
      Wada Masataka、Kurose Shin、Miyazaki Takahiro、Nakajima Shinichiro、Masuda Fumi、Mimura Yu、Nishida Hana、Ogyu Kamiyu、Tsugawa Sakiko、Mashima Yuuki、Plitman Eric、Chakravarty M. Mallar、Mimura Masaru、Noda Yoshihiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 256 Pages: 234-249

    • DOI

      10.1016/j.jad.2019.06.010

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Motor cortex excitability and inhibitory imbalance in autism spectrum disorder assessed with transcranial magnetic stimulation: a systematic review2019

    • Author(s)
      Masuda Fumi、Nakajima Shinichiro、Miyazaki Takahiro、Yoshida Kazunari、Tsugawa Sakiko、Wada Masataka、Ogyu Kamiyu、Croarkin Paul E.、Blumberger Daniel M.、Daskalakis Zafiris J.、Mimura Masaru、Noda Yoshihiro
    • Journal Title

      Translational Psychiatry

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41398-019-0444-3

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study2019

    • Author(s)
      Kaster Tyler S.、Downar Jonathan、Vila-Rodriguez Fidel、Thorpe Kevin E.、Feffer Kfir、Noda Yoshihiro、Giacobbe Peter、Knyahnytska Yuliya、Kennedy Sidney H.、Lam Raymond W.、Daskalakis Zafiris J.、Blumberger Daniel M.
    • Journal Title

      American Journal of Psychiatry

      Volume: 176 Issue: 5 Pages: 367-375

    • DOI

      10.1176/appi.ajp.2018.18091096

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical effectiveness of repetitive transcranial magnetic stimulation treatment in children and adolescents with neurodevelopmental disorders: A systematic review2019

    • Author(s)
      Masuda Fumi、Nakajima Shinichiro、Miyazaki Takahiro、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Tsugawa Sakiko、Croarkin Paul E、Mimura Masaru、Noda Yoshihiro
    • Journal Title

      Autism

      Volume: なし Issue: 7 Pages: 1614-1629

    • DOI

      10.1177/1362361318822502

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effectiveness of the prefrontal repetitive transcranial magnetic stimulation on cognitive profiles in depression, schizophrenia, and Alzheimer's disease: A systematic review2019

    • Author(s)
      Iimori Takashi、Nakajima Shinichiro、Miyazaki Takahiro、Tarumi Ryosuke、Ogyu Kamiyu、Wada Masataka、Tsugawa Sakiko、Masuda Fumi、Daskalakis Zafiris J.、Blumberger Daniel M.、Mimura Masaru、Noda Yoshihiro
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 88 Pages: 31-40

    • DOI

      10.1016/j.pnpbp.2018.06.014

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced theta-gamma coupling associated with hippocampal volume increase following high-frequency left prefrontal repetitive transcranial magnetic stimulation in patients with major depression.2018

    • Author(s)
      Noda Y, Zomorrodi R, Daskalakis ZJ, Blumberger DM, Nakamura M.
    • Journal Title

      Int J Psychophysiol.

      Volume: 133 Pages: 169-174

    • DOI

      10.1016/j.ijpsycho.2018.07.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessment of neuroplasticity in late-life depression with transcranial magnetic stimulation2018

    • Author(s)
      Bhandari Apoorva、Lissemore Jennifer I.、Rajji Tarek K.、Mulsant Benoit H.、Cash Robin F.H.、Noda Yoshihiro、Zomorrodi Reza、Karp Jordan F.、Lenze Eric J.、Reynolds Charles F.、Daskalakis Zafiris J.、Blumberger Daniel M.
    • Journal Title

      Journal of Psychiatric Research

      Volume: 105 Pages: 63-70

    • DOI

      10.1016/j.jpsychires.2018.08.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Efficacy, tolerability, and cognitive effects of deep transcranial magnetic stimulation for late-life depression: a prospective randomized controlled trial2018

    • Author(s)
      Kaster Tyler S.、Daskalakis Zafiris J.、Noda Yoshihiro、Knyahnytska Yuliya、Downar Jonathan、Rajji Tarek K.、Levkovitz Yechiel、Zangen Abraham、Butters Meryl A.、Mulsant Benoit H.、Blumberger Daniel M.
    • Journal Title

      Neuropsychopharmacology

      Volume: 43 Issue: 11 Pages: 2231-2238

    • DOI

      10.1038/s41386-018-0121-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reduced GABAergic cortical inhibition in aging and depression2018

    • Author(s)
      Lissemore Jennifer I.、Bhandari Apoorva、Mulsant Benoit H.、Lenze Eric J.、Reynolds Charles F.、Karp Jordan F.、Rajji Tarek K.、Noda Yoshihiro、Zomorrodi Reza、Sibille Etienne、Daskalakis Zafiris J.、Blumberger Daniel M.
    • Journal Title

      Neuropsychopharmacology

      Volume: 43 Issue: 11 Pages: 2277-2284

    • DOI

      10.1038/s41386-018-0093-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial2018

    • Author(s)
      Blumberger Daniel M、Vila-Rodriguez Fidel、Thorpe Kevin E、Feffer Kfir、Noda Yoshihiro、Giacobbe Peter、Knyahnytska Yuliya、Kennedy Sidney H、Lam Raymond W、Daskalakis Zafiris J、Downar Jonathan
    • Journal Title

      The Lancet

      Volume: 391 Issue: 10131 Pages: 1683-1692

    • DOI

      10.1016/s0140-6736(18)30295-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation2018

    • Author(s)
      Noda Yoshihiro、Zomorrodi Reza、Vila-Rodriguez Fidel、Downar Jonathan、Farzan Faranak、Cash Robin F.H.、Rajji Tarek K.、Daskalakis Zafiris J.、Blumberger Daniel M.
    • Journal Title

      Depression and Anxiety

      Volume: 35 Issue: 5 Pages: 448-456

    • DOI

      10.1002/da.22738

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Neurophysiological research using TMS and its clinical application to psychiatric field2020

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 50th Annual Meeting of Japanese Society of Clinical Neurophysiology
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Evidence for rTMS treatment of psychiatric disorders2020

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 50th Annual Meeting of Japanese Society of Clinical Neurophysiology
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Current status and issues of rTMS in psychiatric treatment2020

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 116th Annual Meeting of the Japanese Society of Psychiatry and Neurology
    • Related Report
      2020 Annual Research Report
  • [Presentation] Toward state-of-the-art neuromodulation research from Japan2020

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 116th Annual Meeting of the Japanese Society of Psychiatry and Neurology
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reduced prefrontal neuroplasticity indexed by paired associative stimulation in patients with depression: a TMS-EEG study2020

    • Author(s)
      Noda Yoshihiro
    • Organizer
      NPBPPP 2020 Joint conference
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neuromodulation including transcranial magnetic stimulation for psychiatric disorders.2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 117th Academic Meeting of Tokyo Psychiatric Association
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Clinical neurophysiology with various TMS paradigms and technological development of rTMS2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 49th Annual Meeting of Japanese Society of Clinical Neurophysiology (JSCN)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Basics of TMS and its clinical application in neuroscience.2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 49th Annual Meeting of Japanese Society of Clinical Neurophysiology (JSCN)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Future Perspective on TMS as Neuromodulation for Psychiatric Disorders. Efficacy and safety of iTBS for treatment-resistant depression: a THREE-D randomized non-inferiority trial.2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 49th Annual Meeting of Japanese Society of Neuropsychopharmacology
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Efficacy and Effectiveness of rTMS therapy reviewed from EBM.2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 16th Annual Meeting of Japanese Society of Mood Disorders
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Guidepost for clinical application of rTMS therapy in Japan2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 115th Annual Meeting of the Japanese Society of Psychiatry and Neurology
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] The possibility of neuromodulation for treatment resistant depression.2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 115th Annual Meeting of the Japanese Society of Psychiatry and Neurology
    • Related Report
      2019 Research-status Report
  • [Presentation] Evaluation and induction of neuroplasticity in patients with depression: a combined TMS-EEG study.2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 14th Annual Meeting of World Congress of Biological Psychiatry (WFSBP)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effectiveness of the prefrontal rTMS on cognitive functions in depression, schizophrenia, and Alzheimer's disease and Investigation of the impaired prefrontal neuroplasticity in treatment-resistant depression using combined TMS-EEG2019

    • Author(s)
      Noda Yoshihiro
    • Organizer
      3rd International Brain Stimulation Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Repetitive Transcranial Magnetic Stimulation (rTMS): Past, Present, and Future2018

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The 31st Annual Meeting of Japanese Society of General Hospital Psychiatry
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Neurophysiological study in psychiatric disorders using combined TMS-EEG2018

    • Author(s)
      Noda Yoshihiro
    • Organizer
      The Joint Congress of the 40th Annual Meeting of Japanese Society of Biological Psychiatry and the 61st Annual Meeting of the Japanese Society for Neurochemistry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] Multidisciplinary Translational Research Lab

    • URL

      http://psy.keiomed.jp/mtr-lab_mri-tms-eeg.html

    • Related Report
      2019 Research-status Report 2018 Research-status Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/nodayoshihiro/?lang=japanese

    • Related Report
      2018 Research-status Report
  • [Remarks] ResearchGate

    • URL

      https://www.researchgate.net/profile/Yoshihiro_Noda2

    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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