Development of the novel genetic test for the leukemia after therapy and the analysis of its clinical significance
| Project/Area Number |
18K15390
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 52010:General internal medicine-related
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
Shumpei Mizuta 神戸大学, 保健学研究科, 研究員 (10782138)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 微小残存病変 / 遺伝子検査 / 造血器腫瘍 / ゲノム解析 / IL3/IGH / 遺伝子異常の検出 / 白血病 / 治療効果判定 |
|---|
| Outline of Final Research Achievements |
Disease status of leukemia is judged by the type of genetic abnormalities and the degree of therapeutic effect, but there are a lot of genetic abnormalities and detecting method is not standardized. To provide optimal medicine for patients with leukemia, optimal genetic test is required depending on indivisual patients. This study was performed by focusing on the detection sensitivity and feasibility to enable genetic test even in the general hospitals. Introduction of the testing method proposed in this study will be expected to contribute to tailor-made medicine.
|
| Academic Significance and Societal Importance of the Research Achievements |
遺伝子異常は基本的にはgenomic DNAを用いられるが、キメラ遺伝子はRNAを用いて解析されることが一般的である。本研究では種々の造血器腫瘍においてgenomic DNA, RNAの両者を測定することで、上記の一般論が必ずしも適切ではなく、疾患に応じてより有用な方法を選択する重要性を示した。また、これまで遺伝子異常に基づいた治療後の検査が為されることがなかったIGH/IL3転座を伴う白血病の新規検査法を報告した。本研究内では一般病院でも実施可能であるかを重視して新規検査法を開発しており、将来的には遺伝子異常に基づいた診療を普及させる可能性がある。
|
Report
(4 results)
Research Products
(15 results)
-
[Journal Article] VS38 staining contributes to a novel gating strategy in flow cytometry for small B cell lymphoma, especially in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia2021
Author(s)
Shumpei Mizuta, Noriko Yamane, Saya Mononobe, Asami Watanabe, Shinichiro Matsuki, Takao Komai, Yusuke Koba, Sachiko Mitani, Takahito Kawata, Akira Tamekane, Mitsumasa Watanabe
-
Journal Title
Cytometry Part B: Clinical Cytometry
Volume: -
Issue: 1
Pages: 50-61
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
