The rule of microRNA links between platelets and infection..diseaese
Project/Area Number |
18K15395
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52010:General internal medicine-related
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Research Institution | Kagoshima University |
Principal Investigator |
Koriyama Toyoyasu 鹿児島大学, 医歯学域鹿児島大学病院, 臨床検査技師 (60723616)
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Project Period (FY) |
2018-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | microRNA / マクロファージ / RICTOR / サイトカイン / 血小板 / 炎症 / 感染症 |
Outline of Final Research Achievements |
The aim of this study is to "elucidate of the molecular and functional mechanism of changes caused by Legionella infected macrophage cells" . First, we demonstrated whether microRNAs released from bacteria infected immune cells can serve as a tool for platelet-cell communication in vitro. Our study revealed the involvement of miR-218 in regulating the inflammatory response of macrophages against L. pneumophila infection.Further, we firstly revealed the role of RICTOR regulated by miR-218 expression.
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Academic Significance and Societal Importance of the Research Achievements |
本研究はL. pneumophila 感染によるマクロファージのサイトカイン産生の制御に、miR-218が関与することと、miR-218で発現が抑制されるRICTORの役割を初めて明らかにした。これまでL. pneumophila 以外の細菌感染時における免疫応答でmiR-155やmiR-146が重要な役割を担うことが報告されているが、mTOR関連分子RICTORの細菌感染への役割については報告がない。増殖、生存シグナルを担うRICTORと感染症への関与の可能性を見出せた点は興味深い
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Liver abscess due to Sterigmatomyces halophilus in a boy with acute lymphoblastic leukemia.2019
Author(s)
Imashioya T, Kodama Y, Ooka T, Nakagawa S, Nishikawa T, Tanabe T, Okamoto Y, Imuta N, Kirishima M, Tanimoto A, Koriyama T, Nishi J, Kawano Y.
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Journal Title
J Infect Chemother
Volume: 25(12)
Issue: 12
Pages: 1047-1049
DOI
Related Report
Peer Reviewed
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