| Project/Area Number |
18K15427
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 動脈硬化 / 頸動脈狭窄症 / 動脈硬化症 / アテローム血栓症 / DNAメチローム / エピゲノム / 細胞老化 / メチローム / 老化 / ミトコンドリアDNA / エピジェネティクス |
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| Outline of Final Research Achievements |
We elucidated that a specific metabolite named X is significantly increased in the whole blood of the patients of carotid artery stenosis (CAS). We further analyzed the association between X level and other atherosclerotic diseases; coronary artery disease (CAD), peripheral arterial disease (PAD), and cerebrovascular disease (CVD). It was elucidated that X was also associated with CAD, PAD, or CVD.
In conclusion, X was associated with atherosclerotic diseases, and reflected the progression of atherosclerosis.
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| Academic Significance and Societal Importance of the Research Achievements |
頸動脈狭窄症、冠動脈疾患、末梢動脈疾患、脳梗塞などの動脈硬化疾患は、その早期発見が予後に直結するため、早期発見が急務である。本研究では、これらの動脈硬化疾患の病勢進行と相関する血中マーカーXを見出し、疾患との関連性を明らかにした。このことによって、動脈硬化症の早期発見の可能性や、早期からの治療介入可能性が示唆された。
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