| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS). Autoantibodies that target the aquaporin 4 water channel (AQP4) expressed in astrocytes cause astrocyte damage, which leads to severe neurological symptoms. We focused on exosomes of the extracellular vesicles, as a candidate factor affecting the disease, and isolated exosomes from human serum. As a preliminary experiment, we performed RNA sequencing of RNA extracted from peripheral blood mononuclear cells. In the future, we will elucidate the involvement of exosomes in the pathogenesis of NMOSD through RNA sequencing of exosomal RNA.
|
