The involvement of exosomes in neuromyelitis optica spectrum disorders
Project/Area Number |
18K15443
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52020:Neurology-related
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Research Institution | Niigata University |
Principal Investigator |
SAJI Etsuji 新潟大学, 医歯学総合病院, 助教 (00706418)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 視神経脊髄炎 / エクソソーム / 細胞外小胞 |
Outline of Final Research Achievements |
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system (CNS). Autoantibodies that target the aquaporin 4 water channel (AQP4) expressed in astrocytes cause astrocyte damage, which leads to severe neurological symptoms. We focused on exosomes of the extracellular vesicles, as a candidate factor affecting the disease, and isolated exosomes from human serum. As a preliminary experiment, we performed RNA sequencing of RNA extracted from peripheral blood mononuclear cells. In the future, we will elucidate the involvement of exosomes in the pathogenesis of NMOSD through RNA sequencing of exosomal RNA.
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Academic Significance and Societal Importance of the Research Achievements |
視神経脊髄炎はアクアポリン4に対する自己抗体が脳のアストロサイトを障害することで重篤な神経障害を引き起こす中枢神経系自己免疫疾患である。アクアポリン4自己抗体の発見により早期診断が可能となり、ステロイドや免疫抑制剤によって再発をある程度抑制できるようになっているが、一部の症例では治療に抵抗性である。NMOSD患者特有のエクソソームのプロファイルを明らかにすることで、より適切な治療選択につなげる可能性がある。
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Report
(4 results)
Research Products
(8 results)