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Transdiagnostic evaluation of atypical sociality at metabolite, neural circuit, and sensory symptoms level

Research Project

Project/Area Number 18K15493
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionShowa University

Principal Investigator

AOKI YUTA  昭和大学, 大学共同利用機関等の部局等, 講師 (70815810)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsASD / ADHD / 発達障害 / 脳画像 / RDoC / 自閉スペクトラム症 / MRI / 注意欠如多動症
Outline of Final Research Achievements

In the current research, we analyzed neuroimaging data from individuals with ASD and those with ADHD on the premise of RDoC. First, we revealed that clinical diagnoses do not guarantee the biological homogeneity in cortical features. This finding suggested the necessity to subtype people to maximize biological homogeneity instead of subjective impression of clinicians. Then, we revealed that neural bases of sensory symptoms composed neural bases of both ASD and ADHD symptoms. This finding indicates that sensory symptoms contribute to developing both ASD and ADHD symptoms, regardless of clinical diagnoses.

Academic Significance and Societal Importance of the Research Achievements

学術的意義:これまでの生物学的研究においては診断間での群間比較が主流だった。しかし、異なる診断感で類似性した症状形成基盤があることや生物学的特徴を診断が保証しないことを示した本研究の結果は、群間比較の結果の解釈が限定的であることを意味している。将来的には、診断ベースではなく生物学的同質性保証したグループで解析を実施する必要性があるという方向性を示すことができた。
社会的意義:臨床診断によって対応が治療方針や対応が変わる意義は神経科学的には乏しいというメッセージになったと考えている。診断中心から症状や生物学的特徴を中心において正確な医療を提供する必要性を示した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 Other

All Int'l Joint Research (6 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (6 results) (of which Int'l Joint Research: 5 results)

  • [Int'l Joint Research] University of Southampton(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] New York University/The Child Mind Institute,(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Heinrich Heine University Dusseldorf(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Southampton(イタリア)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Dusseldorf(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Child Mind Institute/New York University(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Systematic Review and Meta-analysis: Resting-State Functional Magnetic Resonance Imaging Studies of Attention-Deficit/Hyperactivity Disorder2021

    • Author(s)
      Cortese Samuele、Aoki Yuta Y.、Itahashi Takashi、Castellanos F. Xavier、Eickhoff Simon B.
    • Journal Title

      Journal of the American Academy of Child & Adolescent Psychiatry

      Volume: 60 Issue: 1 Pages: 61-75

    • DOI

      10.1016/j.jaac.2020.08.014

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile.2020

    • Author(s)
      Haruhisa Ohta, Yuta Y Aoki, Takashi Itahashi, Chieko Kanai, Junya Fujino, Motoaki Nakamura, Nobumasa Kato, Ryu-Ichiro Hashimoto.
    • Journal Title

      Mol Autism

      Volume: 11 Issue: 1 Pages: 77-77

    • DOI

      10.1186/s13229-020-00379-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural correlates of shared sensory symptoms in autism and attention-deficit/hyperactivity disorder2020

    • Author(s)
      Itahashi Takashi、Fujino Junya、Sato Taku、Ohta Haruhisa、Nakamura Motoaki、Kato Nobumasa、Hashimoto Ryu-Ichiro、Di Martino Adriana、Aoki Yuta Y
    • Journal Title

      Brain Communications

      Volume: 2 Issue: 2

    • DOI

      10.1093/braincomms/fcaa186

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transdiagnostic subtyping of males with developmental disorders using cortical characteristics2020

    • Author(s)
      Itahashi Takashi、Fujino Junya、Hashimoto Ryu-ichiro、Tachibana Yoshiyuki、Sato Taku、Ohta Haruhisa、Nakamura Motoaki、Kato Nobumasa、Eickhoff Simon B.、Cortese Samuele、Aoki Yuta Y.
    • Journal Title

      NeuroImage: Clinical

      Volume: 27 Pages: 102288-102288

    • DOI

      10.1016/j.nicl.2020.102288

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cortical surface architecture endophenotype and correlates of clinical diagnosis of autism spectrum disorder.2019

    • Author(s)
      Yamagata B, Itahashi T, Fujino J, Ohta H, Takashio O, Nakamura M, Kato N, Mimura M, Hashimoto RI, Aoki YY.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 73 Issue: 7 Pages: 409-415

    • DOI

      10.1111/pcn.12854

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Transdiagnostic clustering of individuals with ASD and those with ADHD2020

    • Author(s)
      Yuta Aoki
    • Organizer
      Japanese Society for Neuroscience
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cortical surface architecture endophenotype and correlates of clinical diagnosis of autism spectrum disorder2019

    • Author(s)
      Yuta Aoki, Bun Yamagata, Takashi Itahashi, Junya Fujino, Haruhisa Ohta, Osamu Takashio, Motoaki Nakamura, Nobumasa Kato, Masaru Mimura, Ryu-ichiro Hashimoto
    • Organizer
      25TH ANNUAL MEETING OF THE ORGANIZATION FOR HUMAN BRAIN MAPPING
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cortical Surface Architecture Endophenotype and Correlates of Clinical Diagnosis of Autism Spectrum Disorder2019

    • Author(s)
      Yuta Aoki, Bun Yamagata, Takashi Itahashi, Junya Fujino, Haruhisa Ohta, Osamu Takashio, Motoaki Nakamura, Masaru Mimura, Ryu-ichiro Hashimoto, and Nobumasa Kato
    • Organizer
      INSAR 2019 ANNUAL MEETING
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cortical Surface Architecture Endophenotype and Correlates of Clinical Diagnosis of Autism Spectrum Disorder2019

    • Author(s)
      Yuta Y. Aoki, Bun Yamagata, Takashi Itahashi, Junya Fujino, Haruhisa Ohta, Osamu Takashio, Motoaki Nakamura, Masaru Mimura, Ryu-ichiro Hashimoto, and Nobumasa Kato
    • Organizer
      6th Congress of AsCNP
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 超診断的な症状ー脳関係および診断の影響2019

    • Author(s)
      青木悠太
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Cortical Surface Architecture Endophenotype and Correlates of Clinical Diagnosis of Autism Spectrum Disorder2019

    • Author(s)
      Yuta Aoki, Bun Yamagata, Takashi Itahashi, Junya Fujino, Haruhisa Ohta, Osamu Takashio, Motoaki Nakamura, Nobumasa Kato, Masaru Mimura, Ryu-ichiro Hashimoto
    • Organizer
      International Society for Autism Research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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