Characterization of subcortical structures in clinical high-risk state for psychosis using Japanese multicenter data toward clinical application

• Project/Area Number: 18K15509
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: University of Toyama
• Principal Investigator: Sasabayashi Daiki 富山大学, 学術研究部医学系, 助教 (80801414)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 統合失調症 / 精神病発症危険状態 / 大脳皮質下領域体積 / 多施設共同研究 / 側性 / MRI / 早期介入 / 病態解明 / ARMS / 精神病発症危険群 / 磁気共鳴画像 / 皮質下体積 / 皮質下構造

Outline of Final Research Achievements

We organized a Japanese multicenter study (University of Toyama, Toho University, Tohoku University, and University of Tokyo) and collected magnetic resonance imaging data from 107 individuals with at-risk mental state (ARMS) group and 104 healthy controls. Compared with the controls, ARMS group as a whole exhibited increased volume of the left lateral ventricle, left caudate nucleus, and left globus pallidus, and decresed volume in the right accumbens, possibly reflecting a general vulnerability to mental illness. These major findings were summarized and published as an original article in Schizophrenia Bulletin.

Academic Significance and Societal Importance of the Research Achievements

多数例のARMS 群を対象として発症に先立つ脳形態変化を検出することで、早期の補助診断(脳形態を用いた精神病性障害発症の予測)に寄与することが期待できる。また服薬や疾患経過の影響の少ない ARMS群を対象とすることで、精神病性障害における純粋な疾患過程を反映した所見が得られる可能性がある。その知見を基に動物モデルにおける大脳基底核を含む回路解析などの基礎研究が進むことにより、精神病性障害における脳内神経回路の異常の解明に繋がることが期待される。

Research Products

• [Journal Article] Editorial: Prognostic imaging biomarkers in psychotic disorders (2022)
  • Author(s): Sasabayashi Daiki、Koike Shinsuke、Nakajima Shinichiro、Hirano Yoji
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 1053836-1053836
  • DOI: 10.3389/fpsyt.2022.1053836
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, et al
  • Journal Title: Molecular Psychiatry Volume: in press Issue: 7 Pages: 2950-2967
  • DOI: 10.1038/s41380-022-01572-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased brain gyrification and subsequent relapse in patients with first-episode schizophrenia (2022)
  • Author(s): Sasabayashi Daiki、Takayanagi Yoichiro、Takahashi Tsutomu、Furuichi Atsushi、Kobayashi Haruko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 937605-937605
  • DOI: 10.3389/fpsyt.2022.937605
  • Peer Reviewed / Open Access
• [Journal Article] Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis (2022)
  • Author(s): Baldwin Helen、...Sasabayashi Daiki、...Takahashi Tsutomu、
  • Journal Title: Translational Psychiatry Volume: 12 Issue: 1 Pages: 297-297
  • DOI: 10.1038/s41398-022-02057-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Different Heschl’s Gyrus Duplication Patterns in Deficit and Non-deficit Subtypes of Schizophrenia (2022)
  • Author(s): Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Furuichi Atsushi、Kobayashi Haruko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 867461-867461
  • DOI: 10.3389/fpsyt.2022.867461
  • Peer Reviewed / Open Access
• [Journal Article] Development and validation of a scale of self-alienation-related attributes for the early diagnosis of schizophrenia (2022)
  • Author(s): Nishiyama Shimako、Kurachi Masayoshi、Higuchi Yuko、Takahashi Tsutomu、Sasabayashi Daiki、Mizukami Yuko、Suzuki Michio
  • Journal Title: Journal of Psychiatric Research Volume: 147 Pages: 212-220
  • DOI: 10.1016/j.jpsychires.2022.01.020
  • Peer Reviewed
• [Journal Article] An exploratory, open-label, randomized, multicenter trial of hachimijiogan for mild Alzheimer’s disease (2022)
  • Author(s): Kainuma M, Ouma S, Kawakatsu S, Iritani O, Yamashita KI, Ohara T, Hirano S, Suda S, Hamano T, Hieda S, Yasui M, Yoshiiwa A, Shiota S, Hironishi M, Wada-Isoe K, Sasabayashi D, Yamasaki S, Murata M, Funakoshi K, Hayashi K, Shirafuji N, Sasaki H, Kajimoto Y, Mori Y, Suzuki M, Ito H, Ono K, Tsuboi Y.
  • Journal Title: Frontiers in Pharmacology Volume: 13 Pages: 991982-991982
  • DOI: 10.3389/fphar.2022.991982
  • Peer Reviewed / Open Access
• [Journal Article] Volume reduction of the dorsal lateral prefrontal cortex prior to the onset of frank psychosis in individuals with an at-risk mental state. (2022)
  • Author(s): Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Ohmuro N, Katsura M, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M
  • Journal Title: Cerebral Cortex Volume: in press Issue: 10 Pages: 2245-2253
  • DOI: 10.1093/cercor/bhab353
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders (2022)
  • Author(s): Takahashi Tsutomu、Sasabayashi Daiki、Y?cel Murat、Whittle Sarah、Lorenzetti Valentina、Walterfang Mark、Suzuki Michio、Pantelis Christos、Malhi Gin S.、Allen Nicholas B.
  • Journal Title: Frontiers in Human Neuroscience Volume: 16 Pages: 917270-917270
  • DOI: 10.3389/fnhum.2022.917270
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decreased Cortical Gyrification and Surface Area in the Left Medial Parietal Cortex in Patients with Treatment-Resistant and Ultra-Treatment-Resistant Schizophrenia (2022)
  • Author(s): Kazutoshi Kitajima, Shunsuke Tamura, Daiki Sasabayashi, et al.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 77 Issue: 1 Pages: 2-11
  • DOI: 10.1111/pcn.13482
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools (2022)
  • Author(s): Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 21 Issue: 4 Pages: 539-552
  • DOI: 10.2463/mrms.rev.2021-0050
  • NAID: 130008076114
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Gross anatomical features of the insular cortex in schizophrenia and schizotypal personality disorder: Potential relationships with vulnerability, illness stages, and clinical subtypes (2022)
  • Author(s): Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Furuichi Atsushi、Kobayashi Haruko、Yuasa Yusuke、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 1050712-1050712
  • DOI: 10.3389/fpsyt.2022.1050712
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal changes in brain gyrification in schizophrenia spectrum disorders. (2021)
  • Author(s): Pham TV, Sasabayashi D, Takahashi T, Takayanagi Y, Kubota M, Furuichi A, Kido M, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Aging Neuroscience Volume: 13 Pages: 752575-752575
  • DOI: 10.3389/fnagi.2021.752575
  • Peer Reviewed / Open Access
• [Journal Article] Duration mismatch negativity predicts remission in first-episode schizophrenia patients. (2021)
  • Author(s): Nakajima S, Higuchi Y, Tateno T, Sasabayashi D, Mizukami Y, Nishiyama S, Takahashi T, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 777378-777378
  • DOI: 10.3389/fpsyt.2021.777378
  • Peer Reviewed / Open Access
• [Journal Article] Altered Heschl’s gyrus duplication pattern in first-episode schizophrenia. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Schizophrenia Research Volume: 237 Pages: 174-181
  • DOI: 10.1016/j.schres.2021.09.011
  • Peer Reviewed
• [Journal Article] Potential contribution of pineal atropy and pineal cysts toward vulnerability and clinical characteristics of psychosis. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: NeuroImage: Clinical Volume: 32 Pages: 102805-102805
  • DOI: 10.1016/j.nicl.2021.102805
  • Peer Reviewed / Open Access
• [Journal Article] Reduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor 1-year functional outcomes (2021)
  • Author(s): Sasabayashi D, Takayanagi Y、Takahashi T、Nishiyama S、Mizukami Y、Katagiri N、Tsujino N、Nemoto T、Sakuma A、Katsura M、Ohmuro N、Okada N、Tada M、Suga M、Maikusa N、Koike S、Furuichi A、Kido M、Noguchi K、Yamasue H、Matsumoto K、Mizuno M、Kasai K、Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Issue: 1 Pages: 396-396
  • DOI: 10.1038/s41398-021-01516-2
  • Peer Reviewed / Open Access
• [Journal Article] Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis (2021)
  • Author(s): ENIGMA Clinical High Risk for Psychosis Working Group
  • Journal Title: JAMA Psychiatry Volume: online Issue: 7 Pages: 753-753
  • DOI: 10.1001/jamapsychiatry.2021.0638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia. (2021)
  • Author(s): Higuchi Y, Sumiyoshi T, Tateno T, Nakajima S, Sasabayashi D, Nishiyama S, Mizukami Y, Takahashi T, Suzuki M
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 5 Pages: 327-327
  • DOI: 10.3390/jpm11050327
  • Peer Reviewed / Open Access
• [Journal Article] Reduced Hippocampal Subfield Volume in Schizophrenia and Clinical High-Risk State for Psychosis (2021)
  • Author(s): Sasabayashi D, Yoshimura R, Takahashi T, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Nakamura M, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 642048-642048
  • DOI: 10.3389/fpsyt.2021.642048
  • Peer Reviewed / Open Access
• [Journal Article] Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration (2021)
  • Author(s): Sasabayashi D, Takahashi T, Takayanagi Y, Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Issue: 1 Pages: 176-176
  • DOI: 10.1038/s41398-021-01297-8
  • Peer Reviewed / Open Access
• [Journal Article] Increased Heschl’s Gyrus Duplication in Schizophrenia Spectrum Disorders: A Cross-Sectional MRI Study (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 1 Pages: 40-40
  • DOI: 10.3390/jpm11010040
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study. (2020)
  • Author(s): Takahashi T, Tsugawa S, Nakajima S, Plitman E, Chakravarty MM, Masuda F, Wada M, Kurose S, Ochi R, Matsushita K, Sasabayashi D, Nakamura M, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Hashimoto R, Noguchi K, Fujii S, Mimura M, Noda Y, Suzuki M.
  • Journal Title: Schizophr Res. Volume: 20 Pages: 268-275
  • DOI: 10.1016/j.schres.2020.04.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heschl's gyrus duplication pattern in individuals at risk of developing psychosis and patients with schizophrenia. (2020)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Nishiyama S, Furuichi A, Kido M, Pham T, Kobayashi H, Noguchi K, Suzuki M.
  • Journal Title: Front Behav Neurosci. Volume: 15 Pages: 647069-647069
  • DOI: 10.3389/fnbeh.2021.647069
  • Peer Reviewed / Open Access
• [Journal Article] Features of Duration Mismatch Negativity Around the Onset of Overt Psychotic Disorders: A Longitudinal Study (2020)
  • Author(s): Tateno T, Higuchi Y, Nakajima S, Sasabayashi D, Nakamura M, Ueno M, Mizukami Y, Nishiyama S, Takahashi T, Sumiyoshi T, Suzuki M
  • Journal Title: Cerebral Cortex Volume: 31 Issue: 5 Pages: 2416-2424
  • DOI: 10.1093/cercor/bhaa364
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reduced Cortical Thickness in Schizophrenia and Schizotypal Disorder (2020)
  • Author(s): Takayanagi Yoichiro、Sasabayashi Daiki、Takahashi Tsutomu、Furuichi Atsushi、Kido Mikio、Nishikawa Yumiko、Nakamura Mihoko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Schizophrenia Bulletin Volume: 46 Pages: 387-394
  • DOI: 10.1093/schbul/sbz051
  • Peer Reviewed
• [Journal Article] Subcortical Brain Volume Abnormalities in Individuals With an At-risk Mental State (2020)
  • Author(s): Sasabayashi Daiki、Takayanagi Yoichiro、Takahashi Tsutomu、Katagiri Naoyuki、Sakuma Atsushi、Obara Chika、Katsura Masahiro、Okada Naohiro、Koike Shinsuke、Yamasue Hidenori、Nakamura Mihoko、Furuichi Atsushi、Kido Mikio、Nishikawa Yumiko、Noguchi Kyo、Matsumoto Kazunori、Mizuno Masafumi、Kasai Kiyoto、Suzuki Michio
  • Journal Title: Schizophrenia Bulletin Volume: - Issue: 4 Pages: 547-553
  • DOI: 10.1093/schbul/sbaa011
  • Peer Reviewed / Open Access
• [Journal Article] Pineal Gland Volume in Major Depressive and Bipolar Disorders (2020)
  • Author(s): Takahashi Tsutomu、Sasabayashi Daiki、Yucel Murat、Whittle Sarah、Lorenzetti Valentina、Walterfang Mark、Suzuki Michio、Pantelis Christos、Malhi Gin S.、Allen Nicholas B.
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 450-450
  • DOI: 10.3389/fpsyt.2020.00450
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gray Matter Changes in the Insular Cortex During the Course of the Schizophrenia Spectrum (2020)
  • Author(s): Takahashi Tsutomu、Kido Mikio、Sasabayashi Daiki、Nakamura Mihoko、Furuichi Atsushi、Takayanagi Yoichiro、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 659-659
  • DOI: 10.3389/fpsyt.2020.00659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Support vector machine-based classification of schizophrenia patients and healthy controls using structural magnetic resonance imaging from two independent sites (2020)
  • Author(s): Yamamoto Maeri、Bagarinao Epifanio、Kushima Itaru、Takahashi Tsutomu、Sasabayashi Daiki、Inada Toshiya、Suzuki Michio、Iidaka Tetsuya、Ozaki Norio
  • Journal Title: PLOS ONE Volume: 15 Issue: 11 Pages: 0239615-0239615
  • DOI: 10.1371/journal.pone.0239615
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structural MRI Study of the Planum Temporale in Individuals With an At-Risk Mental State Using Labeled Cortical Distance Mapping (2020)
  • Author(s): Takayanagi Yoichiro、Kulason Sue、Sasabayashi Daiki、Takahashi Tsutomu、Katagiri Naoyuki、Sakuma Atsushi、Ohmuro Noriyuki、Katsura Masahiro、Nishiyama Shimako、Nakamura Mihoko、Kido Mikio、Furuichi Atsushi、Noguchi Kyo、Matsumoto Kazunori、Mizuno Masafumi、Ratnanather J. Tilak、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 593952-593952
  • DOI: 10.3389/fpsyt.2020.593952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 統合失調症スペクトラムにおける脳回形成の変化 (2020)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 根本清貴, 古市厚志, 木戸幹雄, 西川祐美子, 中村美保子, 野口京, 鈴木道雄
  • Journal Title: 精神神経学雑誌 Volume: 122 Pages: 803-811
  • Peer Reviewed
• [Journal Article] 神経発達症を背景に、精神病リスク状態から統合失調症を発症した1例～mismatch negativity測定結果からの考察～ (2020)
  • Author(s): 樋口悠子, 高橋 努, 笹林大樹, 西山志満子, 鈴木道雄
  • Journal Title: 予防精神医学 Volume: 5 Pages: 62-71
  • Peer Reviewed
• [Journal Article] At-risk mental stateにおける脳形態変化: 多施設共同研究 (2020)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 鈴木道雄
  • Journal Title: 日本生物学的精神医学会誌 Volume: 31 Pages: 6-11
  • NAID: 130007822028
• [Journal Article] 精神病性障害における脳溝脳回形成の偏倚に関する研究 (2020)
  • Author(s): 笹林大樹
  • Journal Title: 日本生物学的精神医学会誌 Volume: 31 Pages: 185-185
  • NAID: 130007961370
• [Journal Article] Increased brain gyrification in the schizophrenia spectrum (2019)
  • Author(s): Sasabayashi Daiki、Takayanagi Yoichiro、Takahashi Tsutomu、Nemoto Kiyotaka、Furuichi Atsushi、Kido Mikio、Nishikawa Yumiko、Nakamura Mihoko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Issue: 1 Pages: 70-76
  • DOI: 10.1111/pcn.12939
  • NAID: 40022427818
  • Peer Reviewed / Open Access
• [Journal Article] Potential role of orbitofrontal surface morphology on social and cognitive functions in high-risk subjects for psychosis and schizophrenia patients (2019)
  • Author(s): Takahashi Tsutomu、Nakamura Mihoko、Nishikawa Yumiko、Komori Yuko、Nishiyama Shimako、Takayanagi Yoichiro、Furuichi Atsushi、Kido Mikio、Sasabayashi Daiki、Higuchi Yuko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 283 Pages: 92-95
  • DOI: 10.1016/j.pscychresns.2018.12.002
  • Peer Reviewed
• [Journal Article] Reduced pineal gland volume in schizotypal disorder (2019)
  • Author(s): Takahashi Tsutomu、Nakamura Mihoko、Sasabayashi Daiki、Nishikawa Yumiko、Takayanagi Yoichiro、Furuichi Atsushi、Kido Mikio、Noguchi Kyo、Suzuki Michio
  • Journal Title: Schizophrenia Research Volume: 209 Pages: 289-291
  • DOI: 10.1016/j.schres.2019.05.004
  • Peer Reviewed
• [Journal Article] Association between olfactory sulcus morphology and olfactory functioning in schizophrenia and psychosis high-risk status. (2019)
  • Author(s): Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Furuichi A, Kido M, Mizukami Y, Nishiyama S, Higuchi Y, Tateno T, Itoh H, Noguchi K, Masaoka Y, Suzuki M.
  • Journal Title: Heliyon Volume: 5 Issue: 10 Pages: e02642-e02642
  • DOI: 10.1016/j.heliyon.2019.e02642
  • Peer Reviewed / Open Access
• [Journal Article] Surface morphology of the orbitofrontal cortex in individuals at risk of psychosis: a multicenter study. (2018)
  • Author(s): Nakamura Mihoko, Takahashi Tsutomu, Takayanagi Yoichiro, Sasabayashi Daiki, Katagiri Naoyuki, Sakuma Atsushi, Obara Chika, Koike Shinsuke, Yamasue Hidenori, Furuichi Atsushi, Kido Mikio, Nishikawa Yumiko, Noguchi Kyo, Matsumoto Kazunori, Mizuno Masafumi, Kasai Kiyoto , Suzuki Michio
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience Volume: - Issue: 4 Pages: 397-406
  • DOI: 10.1007/s00406-018-0890-6
  • Peer Reviewed / Open Access
• [Journal Article] Reduced pineal gland volume across the stages of schizophrenia. (2018)
  • Author(s): Takahashi T, Nakamura M, Sasabayashi D, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Furuichi A, Kido M, Noguchi K, Suzuki M.
  • Journal Title: Schizophrenia Research Volume: in press Pages: 163-170
  • DOI: 10.1016/j.schres.2018.11.032
  • Peer Reviewed
• [Journal Article] Pituitary Volume and Socio-Cognitive Functions in Individuals at Risk of Psychosis and Patients With Schizophrenia (2018)
  • Author(s): Takahashi Tsutomu、Higuchi Yuko、Komori Yuko、Nishiyama Shimako、Takayanagi Yoichiro、Sasabayashi Daiki、Kido Mikio、Furuichi Atsushi、Nishikawa Yumiko、Nakamura Mihoko、Noguchi Kyo、Suzuki Michio
  • Journal Title: Frontiers in Psychiatry Volume: 9 Pages: 1-9
  • DOI: 10.3389/fpsyt.2018.00574
  • Peer Reviewed / Open Access
• [Presentation] At-risk mental stateおよび統合失調症 におけるdefault mode network に関連した安静時機能的結合の変化 (2022)
  • Author(s): 笹林大樹, 高橋努, 高柳陽一郎, 根本清貴, 上野摩耶, 古市厚志, 樋口悠子, 水上祐子, 西山志満子, 小林春子, Tien Viet Pham, 野口京, 鈴木道雄
  • Organizer: 第16回統合失調症学会
• [Presentation] 統合失調症を脳のかたちや大きさの特徴から早期に診断することはできるか？ (2022)
  • Author(s): 笹林大樹
  • Organizer: 第16回統合失調症学会
  • Invited
• [Presentation] ARMS群における大脳皮質厚の変化と 1年後の機能的転帰との関連 (2022)
  • Author(s): 笹林大樹
  • Organizer: 第16回統合失調症学会
  • Invited
• [Presentation] At-risk mental stateへの臨床的支援 ～Consultation and Support Service in Toyama (CAST)～ (2022)
  • Author(s): 笹林大樹
  • Organizer: 第200回北陸精神神経学会
• [Presentation] 統合失調症および妄想性障害におけるdefault mode networkに関連した安静時機能的結合性の増加 (2022)
  • Author(s): 笹林大樹, 高橋努, 石戸憩, 白井秀昂, 高柳陽一郎, 根本清貴, 上野摩耶, 古市厚志, 小林春子, 野口京, 鈴木道雄
  • Organizer: 第44回日本生物学的精神医学会
• [Presentation] 精神病性障害における 脳回形成の偏倚に関する研究 (2022)
  • Author(s): 笹林大樹
  • Organizer: 第44回日本生物学的精神医学会
  • Invited
• [Presentation] 初回エピソード統合失調症患者における脳表形態特徴とその後の再燃との関連 (2022)
  • Author(s): 笹林大樹、高柳陽一郎、高橋努、古市厚志、小林春子、湯浅悠介、野口京、鈴木道雄
  • Organizer: 第25回日本精神保健・予防学会学術集会
• [Presentation] 精神病発症危険状態における脳幹体積の検討. (2021)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 藤本岳, 片桐直之, 佐久間篤, 小原千佳, 桂雅宏, 岡田直大, 小池進介, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口京, 山末英典, 笠井清登, 松本和紀, 水野雅文, 鈴木道雄.
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 精神病発症危険状態におけるgyrificationの偏倚と認知機能障害との関連. (2021)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 西山志満子, 水上祐子, 片桐直之, 辻野尚久,根本隆洋, 佐久間篤, 桂雅宏, 大室則幸, 岡田直大, 多田真理子, 管心, 小池進介, 山末英典,松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 統合失調症およびAt-risk mental stateにおける海馬の亜領域の体積変化. (2021)
  • Author(s): 吉村亮, 笹林大樹, 高橋努, 高柳陽一郎, 西山志満子, 樋口悠子, 水上祐子, 古市厚志, 木戸幹雄, 中村美保子, 野口京, 鈴木道雄.
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 若手研究者育成プログラム ショートトーク 精神病性障害における脳溝脳回形成の偏倚に関する研究. (2021)
  • Author(s): 笹林大樹.
  • Organizer: 第43回日本生物学的精神医学会
• [Presentation] 令和3年度若手研究者育成プログラム交流会 精神疾患における脳溝・脳回パターンの偏倚 -疾患横断的・疾患特異的な病態神経回路の解明に向けて-. (2021)
  • Author(s): 笹林大樹.
  • Organizer: 第43回日本生物学的精神医学会
  • Invited
• [Presentation] 初回エピソード統合失調症患者における脳溝・脳回パターンの偏倚とその後の再燃との関連. (2021)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 古市厚志, Tien Viet Pham, 小林春子, 野口京, 鈴木道雄.
  • Organizer: 第24回日本精神保健・予防学会
• [Presentation] 精神疾患における脳溝・脳回パターンの偏倚 -疾患横断的・疾患特異的なバイオマーカー開発に向けて-. (2021)
  • Author(s): 笹林大樹.
  • Organizer: 第198回北陸精神神経学会
  • Invited
• [Presentation] 統合失調症スペクトラムにおける脳幹体積の検討 (2020)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋 努, 藤本岳, 古市厚志, 木戸幹雄, 中村美保子, 野口 京, 鈴木道雄
  • Organizer: 第42回日本生物学的精神医学会
• [Presentation] 精神病性障害における脳溝脳回形成の偏倚に関する研究 (2020)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 小池進介, 山末英典, 片桐直之, 佐久間篤, 小原千佳, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口京, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
  • Organizer: 第42回日本生物学的精神医学会
• [Presentation] Relationship between cortical thickness and functional outcome in individuals at risk of psychosis (2020)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Mizukami Y, Katagiri N, Sakuma A, Obara C, Koike S, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Noguchi K, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M
  • Organizer: The 7th Biennial Schizophrenia International Research Society Conference
  • Int'l Joint Research
• [Presentation] at-risk mental stateにおける脳梁体積の減少：多施設共同研究. (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 片桐直之, 佐久間篤, 小原千佳, 小池進介, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口京, 山末英典, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
  • Organizer: 第14回日本統合失調症学会
• [Presentation] 精神病発症危険状態における脳回形成の偏倚-多施設共同研究-. (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 小池進介, 山末英典, 片桐直之, 佐久間篤, 小原千佳, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口京, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
  • Organizer: 第115回日本精神神経学会
• [Presentation] 初回エピソード統合失調症患者における大脳皮質厚の変化と認知機能障害との関連. (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 西山志満子, 古市厚志, 木戸幹雄, 西川祐美子, 中村美保子, 野口京, 鈴木道雄.
  • Organizer: 第115回日本精神神経学会
• [Presentation] 統合失調症スペクトラムにおける脳梁体積の検討. (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 古市厚志, 木戸幹雄, 西川祐美子, 中村美保子, 野口京, 鈴木道雄.
  • Organizer: 第41回日本生物学的精神医学会
• [Presentation] Brain morphologic changes in individuals with an at-risk mental state: multicenter studies in Japan. (2019)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Nakamura M, Koike S, Kasai K, Matsumoto K, Mizuno M, Suzuki M.
  • Organizer: 第41回日本生物学的精神医学会
  • Invited
• [Presentation] 初回エピソード統合失調症患者における脳幹体積の検討. (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 藤本岳, 古市厚志, 木戸幹雄, 西川祐美子, 中村美保子, 野口京, 鈴木道雄.
  • Organizer: 第23回日本精神保健・予防学会学術集会
• [Presentation] At-risk mental stateにおける大脳皮質厚の変化と認知機能障害との関連. (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 西山志満子, 水上祐子, 片桐直之, 辻野尚久, 根本隆洋, 佐久間篤, 桂雅宏, 大室則幸, 岡田直大, 多田真理子, 管心, 小池進介, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口京, 山末英典, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
  • Organizer: 第23回日本精神保健・予防学会学術集会
• [Presentation] At-risk mental stateにおける脳形態変化：国内多施設共同研究. (2019)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 笠井清登, 松本和紀, 水野雅文, 鈴木道雄.
  • Organizer: 第23回日本精神保健・予防学会学術集会
  • Invited
• [Presentation] Altered subcortical volumes in individuals at risk for psychosis. (2019)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Kasai K, Matsumoto K, Mizuno M, Suzuki M.
  • Organizer: Toyama Forum for Academic Summit on “Dynamic Brain”
• [Presentation] Altered gyrification in the schizophrenia spectrum. (2018)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Takegoshi Y, Matsuda T, Furuichi A, Kido M, Nishikawa Y, Nakamura M, Noguchi K, Suzuki M.
  • Organizer: The 6th Biennial Schizophrenia International Research Society Conference
  • Int'l Joint Research
• [Presentation] Altered Subcortical Volumes in Individuals at Risk for Psychotic Disorders. (2018)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Okada N, Koike S, Katagiri N, Sakuma A, Obara C, Yamasue H, Nakamura M, Furuichi A, Kido M, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Kasai K, Suzuki M.
  • Organizer: 11th International Conference on Early Intervention in Mental Health
  • Int'l Joint Research
• [Presentation] ARMS群における大脳皮質厚の変化と機能的転帰との関連. (2018)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 小森祐子, 片桐直之, 佐久間篤, 小原千佳, 小池進介, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口京, 山末英典, 松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
  • Organizer: 第22回日本精神保健・予防学会学術集会
• [Presentation] 精神病発症危険群における脳回形成の変化と認知機能障害との関連. (2018)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 小森祐子, 西山志満子, 片桐直之, 佐久間篤, 小原千佳, 小池進介, 山末英典, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 笠井清登, 松本和紀, 水野雅文, 鈴木道雄.
  • Organizer: 第18回精神疾患と認知機能研究会