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Investigation of the effects of sports therapy on biological motion perception in schizophrenia

Research Project

Project/Area Number 18K15515
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionTokyo Medical and Dental University (2019-2022)
Kyoto University (2018)

Principal Investigator

Matsumoto Yukiko  東京医科歯科大学, 東京医科歯科大学病院, 助教 (80647131)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords統合失調症 / 認知神経科学 / fMRI / 身体運動知覚 / 社会認知 / 集団スポーツ / 脳MRI
Outline of Final Research Achievements

In a study involving schizophrenia patients and healthy controls engaged in a team sports program, assessments were conducted using biological motion perception tasks, neurocognitive tasks, and social cognitive scales. The results suggested impairments in visual perception and interpersonal cooperation in patients with schizophrenia. Moreover, encoding modeling and natural language analysis were applied to fMRI data during the presentation of natural movies to quantify semantic brain representations, followed by network analysis. The findings revealed a significant reduction in small-worldness of the patients' semantic brain networks, which correlated with the severity of delusions.

Academic Significance and Societal Importance of the Research Achievements

本研究の知見は、チームスポーツにおける統合失調症患者の対人協調性と認知機能の障害の理解の一助となる。また、本研究で用いた自然動画提示下fMRIデータにエンコーディングモデリングと自然言語解析を適用する手法は、患者の陳述に依らず脳活動から直接主観的体験を評価可能であり、精神科医療における新規診断・治療法開発に寄与することが期待される。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2023 2022 2020

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results)

  • [Journal Article] Disorganization of semantic brain networks in schizophrenia revealed by fMRI.2023

    • Author(s)
      Matsumoto Y, Nishida S, Hayashi R, Son S, Murakami A, Yoshikawa N, Ito H, Oishi N, Masuda N, Murai T, Friston K, Nishimoto S, *Takahashi H.
    • Journal Title

      Schizophrenia Bulletin.

      Volume: 49 Issue: 2 Pages: 498-506

    • DOI

      10.1093/schbul/sbac157

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cognition and interpersonal coordination of patients with schizophrenia who have sports habits2020

    • Author(s)
      Fujii Keisuke、Yoshihara Yujiro、Matsumoto Yukiko、Tose Keima、Takeuchi Hideaki、Isobe Masanori、Mizuta Hiroto、Maniwa Daisuke、Okamura Takehiko、Murai Toshiya、Kawahara Yoshinobu、Takahashi Hidehiko
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: e0241863-e0241863

    • DOI

      10.1371/journal.pone.0241863

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 統合失調症の脳内意味ネットワーク異常に関するfMRI研究2022

    • Author(s)
      松本 有紀子、西田 知史、林 隆介、孫 樹洛、村上 晶郎、吉川 長伸、伊藤 寛祥、大石 直哉、増田 直紀 、村井 俊哉、Karl Friston、西本 伸志、高橋 英彦
    • Organizer
      NEURO2022 第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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