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APPLE (Association between the Pathology of Bipolar Disorder and Light Exposure in Daily Life) cohort study

Research Project

Project/Area Number 18K15529
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionFujita Health University

Principal Investigator

Esaki Yuichi  藤田医科大学, 医学部, 客員講師 (60793693)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords精神科 / 概日リズム / 睡眠 / 気分 / 光曝露 / 双極性障害 / リズム / サーカディアンリズム / 精神神経科学
Outline of Final Research Achievements

The aim of this project is to clarify the association between the pathology of bipolar disorder and light exposure in daily life. I found that light exposure is significantly associated with depressive and manic symptoms, sleep quality, and circadian rhythm in patients with bipolar disorder.

Academic Significance and Societal Importance of the Research Achievements

本研究結果により、日常生活の光曝露は双極性障害の病状(睡眠の質、うつ症状、躁症状、クロノタイプ、肥満、再発)と関連していることが明らかになった。双極性障害患者さんは、日中は可能な限り光を浴びて、夜間は真っ暗な部屋で眠ることが病状安定につながることが示唆された。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2022 2021 2020 2019

All Journal Article (10 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results) Presentation (2 results)

  • [Journal Article] Comparison of objective and subjective sleep parameters in patients with bipolar disorder in both euthymic and residual symptomatic periods2022

    • Author(s)
      Fujita Akari、Esaki Yuichi、Obayashi Kenji、Saeki Keigo、Fujita Kiyoshi、Iwata Nakao、Kitajima Tsuyoshi
    • Journal Title

      Journal of Psychiatric Research

      Volume: 145 Pages: 190-196

    • DOI

      10.1016/j.jpsychires.2021.12.015

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effect of morning light exposure on relapse into depressive episode in bipolar disorder2021

    • Author(s)
      Esaki Yuichi、Obayashi Kenji、Saeki Keigo、Fujita Kiyoshi、Iwata Nakao、Kitajima Tsuyoshi
    • Journal Title

      Acta Psychiatrica Scandinavica

      Volume: 143 Issue: 4 Pages: 328-338

    • DOI

      10.1111/acps.13287

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bedroom light exposure at night and obesity in individuals with bipolar disorder: A cross-sectional analysis of the APPLE cohort2021

    • Author(s)
      Esaki Yuichi、Obayashi Kenji、Saeki Keigo、Fujita Kiyoshi、Iwata Nakao、Kitajima Tsuyoshi
    • Journal Title

      Physiology & Behavior

      Volume: 230 Pages: 113281-113281

    • DOI

      10.1016/j.physbeh.2020.113281

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Journal Article] Effect of evening light exposure on sleep in bipolar disorder: A longitudinal analysis for repeated measures in the APPLE cohort2020

    • Author(s)
      Esaki Yuichi、Obayashi Kenji、Saeki Keigo、Fujita Kiyoshi、Iwata Nakao、Kitajima Tsuyoshi
    • Journal Title

      Australian & New Zealand Journal of Psychiatry

      Volume: 55 Issue: 3 Pages: 305-313

    • DOI

      10.1177/0004867420968886

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Higher prevalence of intentional self-harm in bipolar disorder with evening chronotype: A finding from the APPLE cohort study2020

    • Author(s)
      Esaki Yuichi、Obayashi Kenji、Saeki Keigo、Fujita Kiyoshi、Iwata Nakao、Kitajima Tsuyoshi
    • Journal Title

      Journal of Affective Disorders

      Volume: 277 Pages: 727-732

    • DOI

      10.1016/j.jad.2020.08.068

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A double-blind, randomized, placebo-controlled trial of adjunctive blue-blocking glasses for the treatment of sleep and circadian rhythm in patients with bipolar disorder2020

    • Author(s)
      Esaki Y, Takeuchi I, Tsuboi S, Fujita K, Iwata N, Kitajima T.
    • Journal Title

      Bipolar Disord.

      Volume: - Issue: 7 Pages: 739-748

    • DOI

      10.1111/bdi.12912

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between light exposure at night and manic symptoms in bipolar disorder: cross-sectional analysis of the APPLE cohort2020

    • Author(s)
      Esaki Y, Obayashi K, Saeki K, Fujita K, Iwata N, Kitajima T.
    • Journal Title

      Chronobiol Int.

      Volume: - Issue: 6 Pages: 1-10

    • DOI

      10.1080/07420528.2020.1746799

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Utility of the sleep stage sequence preceding sleep onset REM periods for the diagnosis of narcolepsy: a study in a Japanese cohort.2020

    • Author(s)
      Kawai R, Watanabe A, Fujita S, Hirose M, Esaki Y, Arakawa C, Iwata N, Kitajima T.
    • Journal Title

      Sleep Med

      Volume: 68 Pages: 9-17

    • DOI

      10.1016/j.sleep.2019.04.008

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Daytime light exposure in daily life and depressive symptoms in bipolar disorder: A cross-sectional analysis in the APPLE cohort.2019

    • Author(s)
      Esaki Y, Kitajima T, Obayashi K, Saeki K, Fujita K, Iwata N.
    • Journal Title

      J Psychiatr Res.

      Volume: 116 Pages: 151-156

    • DOI

      10.1016/j.jpsychires.2019.06.010

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Light exposure at night and sleep quality in bipolar disorder: The APPLE cohort study.2019

    • Author(s)
      Esaki Y, Kitajima T, Obayashi K, Saeki K, Fujita K, Iwata N
    • Journal Title

      J Affect Disord

      Volume: 257 Pages: 314-320

    • DOI

      10.1016/j.jad.2019.07.031

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 日常生活における夜間光曝露と双極性障害患者の睡眠の質との関連:APPLEコホートスタディ2019

    • Author(s)
      江崎悠一、北島剛司、大林賢史、佐伯圭吾、藤田潔、岩田仲生
    • Organizer
      日本睡眠学会第44回定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 青色光遮断眼鏡による双極性障害患者の睡眠・概日リズムへの影響:無作為化比較試験2019

    • Author(s)
      江崎悠一、竹内一平、坪井宗司、藤田潔、岩田仲生、北島剛司
    • Organizer
      第 26回日本時間生物学会学術大会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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